Failure to deactivate in autism: The co-constitution of self and other
Ahmanson-Lovelace Brain Mapping Center, Department of Psychiatry and Biobehavioral Sciences, NeuroPsychiatric Institute, Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Trends in Cognitive Sciences
(Impact Factor: 21.97).
11/2006; 10(10):431-3. DOI: 10.1016/j.tics.2006.08.002
A new brain imaging study demonstrates that patients with autism have a strikingly different pattern of brain activity compared with control subjects. During cognitive tasks, cortical areas known as the "default state" network--areas that have been implicated in both self-referential processing and processing of socially relevant information--typically reduce their brain activity. In patients with autism, such a reduction was not observed. This new finding indicates that a core deficit in autism might be related to the construal of a sense of self in its relationship with others and will certainly generate exciting new research on the neurobiology of autism.
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