An Outbreak of Epidemic Keratoconjunctivitis Caused by a New Intermediate Adenovirus 22/H8 Identified by Molecular Typing

Institut für Virologie, Medizinische Hochschule Hannover, Hannover, 30625, Germany.
Clinical Infectious Diseases (Impact Factor: 8.89). 11/2006; 43(7):e64-6. DOI: 10.1086/507533
Source: PubMed


In a 4-week period, 12 patients contracted adenoviral keratoconjunctivitis. Eight of these patients had visited the same ophthalmologist's practice before onset of symptoms. Adenovirus was detected in swab specimens obtained from 9 patients. Sequence-based typing of 2 isolates revealed type 22/H8. This is, to our knowledge, the first report of a keratoconjunctivitis outbreak caused by an intermediate adenovirus type 22/H8.

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    • "Respiratory and gastrointestinal infections by HAdVs can be fatal (Lion, 2014). Ocular infection by HAdV species D (HAdV-D) types 8, 37, 53, 54, 56, and 64 (previously typed as 19a) causes epidemic keratoconjunctivitis (EKC) (Desmyter et al., 1974; Engelmann et al., 2006; Jawetz et al., 1955; Kaneko et al., 2009; Mitsui and Jawetz, 1957; Robinson et al., 2009b, 2011; Walsh et al., 2009; Zhou et al., 2012), a severe, hyper-acute infection of the conjunctiva and cornea (Butt and Chodosh, 2006). "
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    • "Detailed understanding of the molecular mechanisms allowing these new pathogens to emerge has come from such analyses. Examples of the genome characterization of emergent pathogens include (1) HAdV-D53, a highly contagious epidemic keratoconjunctivitis (EKC) pathogen (Engelmann et al., 2006) that is a recombinant of at least three parents (Walsh et al., 2009); (2) HAdV-D56, an emergent acute respiratory disease (ARD) and EKC pathogen (Henquell et al., 2009) that is a recombinant of three parents (Robinson et al., 2011); and (3) HAdV-B55, an emergent ARD pathogen (Yang et al., 2009; Zhu et al., 2009) that is a recombinant of two parents (Walsh et al., 2010). "
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    • "In 2005, HAdV-D53 was isolated from a patient with EKC [13]. HAdV-D53 is a new EKC-associated HAdV type with a recombinant genome consisting of sequences derived from the non-EKC-type HAdV-D22 (coding for the neutralization determinant) and the EKC-associated types HAdV-D8 and HAdV-D37, which code for the binding sites to the primary cellular receptor (α2,3-linked sialic acid) and the secondary receptor [3]. "
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