Article

Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimesterof pregnancy?

Department of Obstetrics and Gynecology, Fatih University, İstanbul, Istanbul, Turkey
International Urogynecology Journal (Impact Factor: 2.16). 06/2007; 18(5):525-9. DOI: 10.1007/s00192-006-0190-y
Source: PubMed

ABSTRACT Untreated asymptomatic bacteriuria has been associated with acute pyelonephritis, which may have a role in many maternal and fetal complications. Acute pyelonephritis in pregnancy is related to anemia, septicemia, transient renal dysfunction, and pulmonary insufficiency. A randomized study was conducted to assess the clinical and microbiological efficacy of a single dose of fosfomycin trometamol for the treatment of asymptomatic bacteriuria in the second trimester of pregnancy compared with a 5-day regimen of cefuroxime axetyl. Forty-four women received fosfomycin trometamol and 40 women received cefuroxime axetyl. There were no statistically significant differences between both groups regarding the mean age and mean duration of pregnancy. Therapeutic success was achieved in 93.2% of the patients treated with fosfomycin trometamol vs 95% of those treated with cefuroxime axetyl. A single dose of fosfomycin trometamol is a safe and effective alternative in the treatment of asymptomatic urinary tract infections in the second trimester of pregnancy.

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    ABSTRACT: To compare the efficacy of fosfomycin trometamol, cefuroxime axetil, and amoxicillin clavulanate antibiotics, and to assess the difference in patient compliance, in the treatment of urinary tract infections during pregnancy. Between September 2007 and May 2008, 90 out of 324 pregnant women with complaints of lower urinary tract infection, who were followed at the outpatient clinic or referred to the emergency department of Vakif Gureba Education and Research Hospital, were enrolled in a prospective study. Patients were randomized into 3 equal groups for treatment with single-dose fosfomycin trometamol, or 5-day courses of amoxicillin clavulanate or cefuroxime axetil. After follow-up, study data were obtained for 28, 27, and 29 patients, respectively. The treatment groups did not differ significantly in terms of demographics, clinical success rate, microbiological cure rate, or adverse effects. Significantly higher drug compliance was observed in the fosfomycin trometamol group than in the other 2 groups (P<0.05). Treatment with a single dose of fosfomycin trometamol was as effective for UTI as the standard course of treatment with amoxicillin clavulanate or cefuroxime axetil. Fosfomycin trometamol may be a preferable treatment for UTI because of its simpler use and better rates of compliance.
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    ABSTRACT: Introduction: The efficacy and tolerability of fosfomycin in a single dose of 3 g was compared with ciprofloxasin 500 mg for three days in the treatment of adult female patient with uncomplicated urinary infections. Materials and Methods: 100 female patients with a mean age of 36.2±4.53 years who presented symptoms of dysuria and frequency with documented pyuria and bacteriuria on urinalysis (>100.000 cfu/ml of urine) were initially included in the study. The total number of clinically and bacteriologically evaluable patient was 100, of which 50 received fosfomycin trometamol and 50 ciprofloxacin. Results: One to two days after the double blind medication schedule for seven days 48 of 50 patients (96%) in the fosfomycin trometamol group and 47 of 50 patients (94%) in the ciprofloxacin group were clinically cured. No side effect was seen in fosfomycin group but gastrointestinal side effect was seen in 3 patients in ciprofloxacin group. Conclusion: Single dose fosfomycin in treatment of uncomplicated urinary infection in women shows that similar efficacy and more tolerability than does three days ciprofloxacin treatment.
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