Selenium supplementation and blood rheological improvement in Japanese adults.
ABSTRACT In order to study the prevention effect of selenium in the development of cardiovascular disease, we investigated the effects of selenium supplementation on the blood rheological properties. Eleven healthy adults were administered with 200 microg of selenium in the form of selenium yeast per day for 1 wk. Before and after the supplementation, serum selenium concentration, glutathione peroxidase (GPx) activity, biochemical indices, and the blood fluidity of the subjects were measured. The blood fluidity was measured using a (microchannel array flow analyzer) by the passage time of 100 microL of heparinized whole blood through the microchannel array. The selenium supplementation significantly (p = 0.001) shortened the mean blood passage time from 44.0 +/- 5.7 to 37.5 +/- 2.8 s. Serum selenium concentration significantly (p = 0.008) increased from 109.8 +/- 10.2 to 124.5 +/- 16.7 microg/L. Meanwhile, the GPx activity did not increased significantly (p = 0.058). The mean GPx activity of the subjects before supplementation was 171.0 +/- 16.1 Deltammol NADPH/min/L and 180.9 +/- 17.8 Deltammol NADPH/min/L after supplementation. Factor analysis of the passage time and biochemical indices of the subjects showed that blood fluidity improvement was related to the metabolic modification of lipoproteins during the selenium supplementation. These results showed that selenium supplementation improved the blood fluidity, without increasing the GPx activity of the subjects.
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ABSTRACT: To elucidate a physiological function of dried-bonito broth (DBB) on blood fluidity and oxidative stress, we performed a randomized double-blind placebo-controlled study in twenty-four healthy adult subjects. The subjects ingested DBB or a placebo for four weeks, and blood fluidity and oxidative stress were measured before and after ingestion. Blood fluidity was measured using a microchannel array flow analyzer by the passage time of 100 µl of heparinized whole blood through the microchannel array, while oxidative stress was evaluated as a level of deriva-tive of reactive oxygen metabolites (d-ROMs) by a free radical analysis system (FRAS). DBB ingestion significantly shortened the blood passage time from 55.4 ± 3.4 to 47.6 ± 2.0 sec (mean ± SEM, p < 0.05), while no significant change was observed in the placebo group (52.4 ± 3.4 to 51.4 ± 2.6 sec, mean ± SEM) indicating that DBB amelio-rated blood fluidity. The level of d-ROMs, known as a biomarker of oxidative stress, significantly decreased after DBB ingestion from 337.2 ± 18.5 to 316.5 ± 12.9 Carrotelli units (Carr. U.) (mean ± SEM, p < 0.05), suggesting that DBB reduced oxidative stress. Among subjects with a d-ROMs score > 320, regarded as being in a state of oxidative stress, changes in blood fluidity tended to correlate with changes in d-ROMs score (ρ = 0.55, p = 0.06), showing that blood fluidity may have improved in subjects whose oxidative stress was markedly decreased. These results also showed a possibility that DBB ingestion improved blood fluidity by decreasing oxidative stress. In previous studies, daily DBB ingestion improved various fatigue-related symptoms, so we investigated the effect of DBB on fatigue-related symptoms via a questionnaire survey in the present study. The result of this survey showed that symptoms of shoulder stiffness and visual fatigue were improved only in the DBB group (p < 0.05, p < 0.1, respectively). Insufficient blood circulation is considered to lead to the development of shoulder stiffness, visual fatigue, and other fatigue-related symptoms. Based on these findings, we considered that dietary intake of DBB may improve blood fluidity by reducing oxidative stress and thus might protect against fatigue.Journal of health science 10/2007; 53(5):543-551. DOI:10.1248/jhs.53.543 · 0.80 Impact Factor
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ABSTRACT: During the last decade it has become obvious that, while our lifestyle, including diet, stress, smoking, medical issues, exercise, and genetics are major determinants of human health status, it is diet that plays a central role. The effect of nutrition on human health has received substantial attention, and even ‘traditional’ medicinal philosophies that state that diet and nutrients play only limited roles in human health is being revised. In most developed countries nutritional practices have changed the focus from combating nutrient deficiencies to addressing nutrient requirements for maintaining good health throughout life. The role of selenium (Se) in human health and diseases has been discussed in detail in several recent reviews, with the main conclusion being that Se deficiency is recognised as a global problem which needs solving urgently. Analysing recent publications that relate human health to useful poultry products, it is evident that Se-enriched eggs can be used as an important delivery system of this trace mineral for humans. In particular, developments and commercialisation of organic forms of selenium has initiated a new era in the availability of selenium-enriched products. It has been shown that egg selenium content can be easily manipulated to give increased levels, especially when organic selenium is included in hen's diet at levels that provide 0.3-0.5 ppm Se in feed. As a result, technology for the production of eggs delivering ~50% (30-35 μg) of the human selenium RDA have been developed and successfully tested. Currently companies all over the world market Se-enriched eggs including the UK, Ireland, Malaysia, Thailand, Australia, Turkey, Russia and Ukraine. Prices for enriched eggs vary from country to country, typically being similar to free-range eggs. The scientific, technological and other advantages and limitations of producing designer/modified eggs as functional foods are discussed in this paper.World's Poultry Science Journal 02/2008; 64(01):85 - 98. DOI:10.1017/S0043933907001742 · 1.16 Impact Factor
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ABSTRACT: Selenium (Se) plays an important role in health maintenance, and optimization of Se status of the general population is an urgent task for many countries worldwide. Low Se availability from European soils due to fertilization decreased dramatically. Se availability for plants leads to low Se concentrations in grains and in animal-derived products and ultimately in human diet. Supplementing animal diets with Se in the form of sodium selenite or selenate does not affect substantially Se concentration in eggs, meat, and milk. SeMet represents the major form of Se in animal-derived foods and must be provided with diets for solving Se deficiency problems through production of Se-enriched eggs, meat, and milk. KeywordsSelenium-Antioxidants-Human health-Deficiency12/2009: pages 379-403;