In order to study the prevention effect of selenium in the development of cardiovascular disease, we investigated the effects of selenium supplementation on the blood rheological properties. Eleven healthy adults were administered with 200 microg of selenium in the form of selenium yeast per day for 1 wk. Before and after the supplementation, serum selenium concentration, glutathione peroxidase (GPx) activity, biochemical indices, and the blood fluidity of the subjects were measured. The blood fluidity was measured using a (microchannel array flow analyzer) by the passage time of 100 microL of heparinized whole blood through the microchannel array. The selenium supplementation significantly (p = 0.001) shortened the mean blood passage time from 44.0 +/- 5.7 to 37.5 +/- 2.8 s. Serum selenium concentration significantly (p = 0.008) increased from 109.8 +/- 10.2 to 124.5 +/- 16.7 microg/L. Meanwhile, the GPx activity did not increased significantly (p = 0.058). The mean GPx activity of the subjects before supplementation was 171.0 +/- 16.1 Deltammol NADPH/min/L and 180.9 +/- 17.8 Deltammol NADPH/min/L after supplementation. Factor analysis of the passage time and biochemical indices of the subjects showed that blood fluidity improvement was related to the metabolic modification of lipoproteins during the selenium supplementation. These results showed that selenium supplementation improved the blood fluidity, without increasing the GPx activity of the subjects.
"Selenium (Se) is essential for humans and has been reported to play a beneficial role in the prevention of cardiovascular disease [1-3] and cancer [4-6]. The main Se source for humans comes from diet; however, the Se concentration in foods varies widely and is dependent on the Se concentration of the soil in which the food was grown. "
[Show abstract][Hide abstract] ABSTRACT: Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts.
Selenium-enriched broccoli sprouts were prepared using a sodium selenite solution. Their anticancer properties were evaluated in human prostate cancer cell lines and compared with those of a control broccoli sprout extract.
Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Furthermore, selenium-enriched broccoli sprouts but, not normal broccoli sprouts, induced a downregulation of the survival Akt/mTOR pathway.
Our results suggest that selenium-enriched broccoli sprouts could potentially be used as an alternative selenium source for prostate cancer prevention and therapy.
BMC Cancer 11/2009; 9(1):414. DOI:10.1186/1471-2407-9-414 · 3.36 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: In this study, we conducted a 2 weeks selenium supplementation, to study the effect of selenium supplementation to the levels of PGI2 and TxB2 in human. Two weeks of sodium selenite supplementation can significantly increase the total selenium level in the serum and in the red blood cells. The supplementation also altered the ratio of PGI2 and TxB2 level in the serum. PGI2 level was significantly increased from 382.9 pg/ml before the supplementation to 576.8 pg/ml after the supplementation, while TxB2 level was significantly decreased from 22.4 pg/ml before the supplementation to 15.0 pg/ml after the supplementation. However, there was no significant change in the glutathione peroxidase activity neither in the serum nor in the red blood cells. Despite the controversy about the pathophysiological role of selenium in cardiovascular disease, due to the conflicting result in the previous reports on epidemiological studies of selenium and cardiovascular disease, the results of this study clearly showed that the level of selenium in blood has an effect on the endothelial cells by altering the expression of specific eicosanoids and supports the hypothesis that selenium plays a protective role in vascular disease.
Thrombosis Research 02/2007; 119(3):305-10. DOI:10.1016/j.thromres.2006.02.005 · 2.45 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: To elucidate a physiological function of dried-bonito broth (DBB) on blood fluidity and oxidative stress, we performed a randomized double-blind placebo-controlled study in twenty-four healthy adult subjects. The subjects ingested DBB or a placebo for four weeks, and blood fluidity and oxidative stress were measured before and after ingestion. Blood fluidity was measured using a microchannel array flow analyzer by the passage time of 100 µl of heparinized whole blood through the microchannel array, while oxidative stress was evaluated as a level of deriva-tive of reactive oxygen metabolites (d-ROMs) by a free radical analysis system (FRAS). DBB ingestion significantly shortened the blood passage time from 55.4 ± 3.4 to 47.6 ± 2.0 sec (mean ± SEM, p < 0.05), while no significant change was observed in the placebo group (52.4 ± 3.4 to 51.4 ± 2.6 sec, mean ± SEM) indicating that DBB amelio-rated blood fluidity. The level of d-ROMs, known as a biomarker of oxidative stress, significantly decreased after DBB ingestion from 337.2 ± 18.5 to 316.5 ± 12.9 Carrotelli units (Carr. U.) (mean ± SEM, p < 0.05), suggesting that DBB reduced oxidative stress. Among subjects with a d-ROMs score > 320, regarded as being in a state of oxidative stress, changes in blood fluidity tended to correlate with changes in d-ROMs score (ρ = 0.55, p = 0.06), showing that blood fluidity may have improved in subjects whose oxidative stress was markedly decreased. These results also showed a possibility that DBB ingestion improved blood fluidity by decreasing oxidative stress. In previous studies, daily DBB ingestion improved various fatigue-related symptoms, so we investigated the effect of DBB on fatigue-related symptoms via a questionnaire survey in the present study. The result of this survey showed that symptoms of shoulder stiffness and visual fatigue were improved only in the DBB group (p < 0.05, p < 0.1, respectively). Insufficient blood circulation is considered to lead to the development of shoulder stiffness, visual fatigue, and other fatigue-related symptoms. Based on these findings, we considered that dietary intake of DBB may improve blood fluidity by reducing oxidative stress and thus might protect against fatigue.
Journal of health science 10/2007; 53(5):543-551. DOI:10.1248/jhs.53.543 · 0.80 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.