According to premarketing studies, at least 1% of ziprasidone-treated patients exhibited hypertension; however, this figure is not necessarily attributable to the drug. A PubMed/MEDLINE search yielded no articles describing hypertension as a possible adverse event associated with oral ziprasidone therapy. We describe a 53-year-old African-American woman with hypertension and schizophrenia whose blood pressure increased during ziprasidone therapy. She experienced no similar blood pressure increases during therapy with four other atypical antipsychotics. Her mean systolic blood pressure during ziprasidone treatment (158 mm Hg) was significantly higher than before (141 mm Hg) and after (135 mm Hg) treatment. Also, her mean diastolic blood pressure during ziprasidone treatment (88 mm Hg) was significantly higher than after treatment (79 mm Hg). Linear regression analysis demonstrated that the patient's systolic blood pressure increased significantly with ziprasidone dose (regression coefficient [B] = 0.22 mm Hg x day/mg, 95% confidence interval 0.10-0.34, p=0.001). Thus, after adjusting for the effect of antihypertensive doses, an increase of 40 mg/day in ziprasidone yielded an increase of 8.8 mm Hg in systolic blood pressure. For unknown (perhaps genetic) reasons, this patient may have been particularly sensitive to ziprasidone. Clinicians prescribing ziprasidone in patients with hypertension should be aware that their hypertension could worsen with the addition of ziprasidone. If this occurs, replacement of ziprasidone with a different antipsychotic should be considered.
"Most antipsychotics do not appear to cause elevations of blood pressure in the average patient. This does not rule out elevations in rare patents that may be particularly sensitive to specific antipsychotics (Villanueva et al., 2006). Clozapine is the only antipsychotic that has been consistently associated with hypertension (b5% of patients) (de Leon and Diaz, 2007). "
[Show abstract][Hide abstract] ABSTRACT: A recent Finnish study reported that long-term cumulative exposure to any antipsychotic treatment was related to lower mortality than was no drug exposure. We hypothesize that the antipsychotic 5-HT2A receptor blockade might protect from ischemic heart disease and buffer the deleterious metabolic effects of antipsychotics. The 5-HT2A receptor may be involved in vascular smooth muscle contraction, coronary artery spasms, platelet aggregation and thrombus formation. 5-HT2A receptor blockade might protect from ischemic heart disease by decreasing platelet aggregation and myocardium hypertrophy. Long-term follow-up studies are needed to clearly establish the long-term contribution of the various antipsychotic drugs to ischemic heart disease, and to explore our hypothesis that 5-HT2A receptor blockade may be protective for cardiovascular disease.
Schizophrenia Research 06/2010; 119(1-3):160-3. DOI:10.1016/j.schres.2009.12.005 · 3.92 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Drug-induced hypertension can be the result of increased sympathetic nervous system activity, changes in renal blood flow, retention of salt and water, and other mechanisms. Direct and indirect sympathomimetic drugs, non-steroidal anti-inflammatory drugs, and corticosteroids illustrate these mechanisms. Other drugs, including erythropoietins, anti-psychotic drugs, and antidepressants, can cause clinically important hypertension by mechanisms that are less clearly understood.
Adverse Drug Reaction Bulletin 07/2006; DOI:10.1097/01.fad.0000268335.14214.8b
Miklos Rohla, Alexander Nahler, Thomas Lambert, Christian Reiter, Verena Gammer, Michael Grund, Hermann Blessberger, Jürgen Kammler, Alexander Kypta, Karim Saleh, Kurt Huber, Clemens Steinwender, Thomas W Weiss,
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.