Preeclampsia and subsequent risk of cancer in Utah
The purpose of this study was to determine if preeclampsia is associated with a reduced risk of cancer later in life.
We performed a cohort study where women with preeclampsia over the interval 1947 to 1999 were identified from the Utah Population Database. Preeclamptics (n = 17,432) were matched 1:3 with nonpreeclamptics (n = 52,296) on maternal age and birth year. Pregnancy, demographic, and cancer information was extracted from subjects and their offspring in linked datasets. Relative risk and hazard ratios were calculated.
In a matched analysis using univariable random-effects Poisson regression, preeclampsia was protective against the development of cancer later in life (RR 0.91, 95% CI 0.84-0.99 with P = .027). In a multivariable clustered Cox regression model with the end point of cancer later in life, preeclampsia was associated with a lower risk of cancer (HR 0.92, 95% CI 0.85-0.99 with P = .039). These findings were supported by stratified and competing risk analyses.
Women whose pregnancies were affected by preeclampsia have a decreased risk of developing cancer.
Available from: Rocco C Venuto
- "Multiple observational studies evaluated the possible association between hypertension in pregnancy and cancer risk. Overall, women with preeclampsia were found to be at reduced risk or had no excess risk of cancer when followed by extended periods postpartum [96–99]. This was confirmed by a recent systematic review that found no significant association between preeclampsia and risk of cancer. "
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ABSTRACT: Hypertension is the most common medical disorder encountered during pregnancy. Hypertensive disorders are one of the major causes of pregnancy-related maternal deaths in the United States. We will present a comprehensive update of the literature pertinent to hypertension in pregnancy. The paper begins by defining and classifying hypertensive disorders in pregnancy. The normal vascular and renal physiological changes which occur during pregnancy are detailed. We will summarize the intriguing aspects of pathophysiology of preeclampsia, emphasizing on recent advances in this field. The existing diagnostic tools and the tests which have been proposed for screening preeclampsia are comprehensively described. We also highlight the short- and long-term implications of preeclampsia. Finally, we review the current management guidelines, goals of treatment and describe the potential risks and benefits associated with various antihypertensive drug classes. Preeclampsia still remains an enigma, and the present management focuses on monitoring and treatment of its manifestations. We are hopeful that this in depth critique will stimulate the blossoming research in the field and assist practitioners to identify women at risk and more effectively treat affected individuals.
Journal of pregnancy 05/2012; 2012(4):105918. DOI:10.1155/2012/105918
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ABSTRACT: The nature of the firm's strategy is to pursue the firm's rent, which is the goal of the firm's sustainable competitive advantage. The traditional neoclassical economics and RBV studied the derivation of the firm's rent from one aspect. The former thinks rent stems from an imperfectly competitive market structure, and the latter thinks it is resource heterogeneity. This paper suggests that the core of "rent"(or SCA) of the enterprise stems not only from "heterogeneity resources" but also the "integration" of "heterogeneity resources" and other resources in the enterprise. Based on the study of integration mechanism by economics and management methods, this paper suggests the enterprise rent's differential under the integration and nonintegration condition.
Engineering Management Conference, 2004. Proceedings. 2004 IEEE International; 11/2004
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