Article

Preeclampsia and subsequent risk of cancer in Utah

University of Utah, Salt Lake City, Utah, United States
American journal of obstetrics and gynecology (Impact Factor: 3.97). 10/2006; 195(3):691-9. DOI: 10.1016/j.ajog.2006.06.089
Source: PubMed

ABSTRACT The purpose of this study was to determine if preeclampsia is associated with a reduced risk of cancer later in life.
We performed a cohort study where women with preeclampsia over the interval 1947 to 1999 were identified from the Utah Population Database. Preeclamptics (n = 17,432) were matched 1:3 with nonpreeclamptics (n = 52,296) on maternal age and birth year. Pregnancy, demographic, and cancer information was extracted from subjects and their offspring in linked datasets. Relative risk and hazard ratios were calculated.
In a matched analysis using univariable random-effects Poisson regression, preeclampsia was protective against the development of cancer later in life (RR 0.91, 95% CI 0.84-0.99 with P = .027). In a multivariable clustered Cox regression model with the end point of cancer later in life, preeclampsia was associated with a lower risk of cancer (HR 0.92, 95% CI 0.85-0.99 with P = .039). These findings were supported by stratified and competing risk analyses.
Women whose pregnancies were affected by preeclampsia have a decreased risk of developing cancer.

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