Specimen-specific beam models for fast and accurate prediction of human trabecular bone mechanical properties

Institute for Biomedical Engineering, University and ETH Zürich, Moussonstrasse 18, 8044 Zürich, Switzerland.
Bone (Impact Factor: 3.97). 01/2007; 39(6):1182-9. DOI: 10.1016/j.bone.2006.06.033
Source: PubMed


Direct assessment of bone competence in vivo is not possible, hence, it is inevitable to predict it using appropriate simulation techniques. Although accurate estimates of bone competence can be obtained from micro-finite element models (muFE), it is at the expense of large computer efforts. In this study, we investigated the application of structural idealizations to represent individual trabeculae by single elements. The objective was to implement and validate this technique. We scanned 42 human vertebral bone samples (10 mm height, 8 mm diameter) with micro-computed tomography using a 20 microm resolution. After scanning, direct mechanical testing was performed. Topological classification and dilation-based algorithms were used to identify individual rods and plates. Two FE models were created for each specimen. In the first one, each rod-like trabecula was modeled with one thickness-matched beam; each plate-like trabecula was modeled with several beams. From a simulated compression test, assuming one isotropic tissue modulus for all elements, the apparent stiffness was calculated. After reducing the voxel size to 40 microm, a second FE model was created using a standard voxel conversion technique. Again, one tissue modulus was assumed for all elements in all models, and a compression test was simulated. Bone volume fraction ranged from 3.7% to 19.5%; Young's moduli from 43 MPa to 649 MPa. Both models predicted measured apparent moduli equally well (R2 = 0.85), and were in excellent agreement with each other (R2 = 0.97). Tissue modulus was estimated at 9.0 GPa and 10.7 GPa for the beam FE and voxel FE models, respectively. On average, the beam models were solved in 219 s, reducing CPU usage up to 1150-fold as compared to 40 microm voxel FE models. Relative to 20 microm voxel models 10,000-fold reductions can be expected. The presented beam FE model is an abstraction of the intricate real trabecular structure using simple cylindrical beam elements. Nevertheless, it enabled an accurate prediction of global mechanical properties of microstructural bone. The strong reduction in CPU time provides the means to increase throughput, to analyze multiple loading configuration and to increase sample size, without increasing computational costs. With upcoming in vivo high-resolution imaging systems, this model has the potential to become a standard for mechanical characterization of bone.

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Available from: Harry Van Lenthe, Oct 13, 2015
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    • "The removal of marrow is intended to facilitate the microstructural analyses of the sample before and after mechanical test. All the prepared samples were wrapped in saline dampened gauze and stored in airtight container at À 20 1C (Teo et al., 2007; van Lenthe et al., 2006). Analytical balance with Archimedes's method was used to determine the porosity and apparent density of the samples. "
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    ABSTRACT: The present study reports the effects of combined torsional and compressive cyclic loading on trabecular bone in order to mimic true physiological conditions and thereby provides improved data that represents clinical and real life conditions. However, only compressive behaviour is evaluated in most previous studies of bone mechanics. From the monotonic evaluation, it is observed that lower stress is needed for the onset of microcrack in the sample under torsional loading, compared to the stress needed in compression. Trabecular bone samples were subjected to a combination of torsion and compression fatigue at different stress levels during which they were compared to compressive axial fatigue. The stress levels were determined by considering the monotonic strength at 25-50% for both compressive and shear stresses. Significant decrease in fatigue lifetime is observed in between samples of pure compression fatigue and those with superpositioned torsional loading (p<0.05). The reduction in fatigue lifetime became more evident at a high torsional stress level. In this case, the failure of the sample is said to be 'torsional dominant'. Fatigue behaviour of bovine trabecular bone begins with plastic deformation, followed by strain accumulation and modulus reduction. As the strain rate increases, more energy dissipates and the sample finally failed. Further, the analysis of fractograph revealed something on the trabeculae by bending in sample with superpositioned torsional loading. In conclusion, torsional loading decreases the quality of the trabecular properties in terms of stiffness, life and structural integrity. It is hoped that results from this study will improve the understanding of the behaviour of trabecular bone under combined fatigue and help to develop future assessments of trabecular failure.
    Journal of the Mechanical Behavior of Biomedical Materials 09/2015; 54:21. DOI:10.1016/j.jmbbm.2015.09.006 · 3.42 Impact Factor
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    • "Furthermore, successful validation for μCT based FE models of trabecular bone, in which bone trabeculae had been modeled consisting of homogenous material properties only (Chevalier et al., 2007; Van Lenthe et al., 2006), indicates that other modeling features must cause the present mismatch between in silico and experimental data of bone–implant systems. One modeling feature that may explain the current mismatch is the presence of damage. "
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    ABSTRACT: Secure fixation of fractured osteoporotic bone is a serious clinical challenge mainly because the reduced mechanical quality of low-density bone hampers proper implant fixation. Recent experimental findings have shown strong evidence for a rather complex bone-implant interface contact behavior, with frictional and non-linear mechanical properties. Furthermore, the bone microarchitecture is highly diverse even within the same anatomical site of a specific individual. Due to this intrinsic variability experimental studies that could analyze in detail the contributions of screw designs and thread geometry would require a very large amount of bone specimens; this hampers finding potential improvements for implant fixation. As a complementary approach, computational methods may overcome this limitation, since the same specimen can be tested repeatedly in numerous configurations and under various loading conditions. Recent advances in imaging techniques combined with parallel computing methods have enabled the creation of high-resolution finite-element models that are able to represent bone-implant systems in great detail. Yet, the predictive power of the mechanical competence of bone-implant systems is still limited, both on the apparent level and on the local microstructural level. The current strategy in high-resolution FE models to model the bone-implant interface, employing fully bonded cube-like elements, needs to be reconsidered, refined and validated, such that it mimics more closely the actual non-linear mechanical behavior as observed in vitro in order to exploit the full potential of numeric models as an effective, complementary research method to physical in vitro models.
    Journal of Biomechanics 12/2014; 48(5). DOI:10.1016/j.jbiomech.2014.12.008 · 2.75 Impact Factor
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    • "Both phenomenological and mechanistic formulations of mechanical adaptation of bone have been developed for further understanding this adaptive response (Doblare and Garcia, 2002; Ruimerman et al., 2005; Vahdati and Rouhi, 2009; Jacobs et al., 1997; Tsubota et al., 2009; Beaupre et al., 1990). The mathematical descriptions of mechanically-induced bone adaptation when combined with subject-specific modeling have the potential for being important predictive tools, providing insight into bone remodeling around implants, fracture risk, pre-surgical planning, and mechanical causes of bone pathologies such as osteoporosis (Lenaerts and van Lenthe, 2009; van Lenthe et al., 2006). Particularly in recent years, there has been a paradigm shift from evaluation of medical interventions in the average patient to personalized medicine and tailored therapeutics. "
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    ABSTRACT: The typical bone density patterns in the proximal femur can be explained using bone remodeling simulations incorporating a load-adaptive response. Yet, subject-specific variations in bone density have not received much attention. Therefore, the objective of this study was to quantify to what extent subject-specific bone geometry and subject-specific musculoskeletal loading affect the predicted bone density distribution. To accomplish this goal, a computational bone remodeling scheme was combined with gait analysis and a subject-specific musculoskeletal model. Finite element models incorporating the subject-specific geometry as well as the subject-specific hip contact forces and associated muscle forces were used to predict the density distribution in the proximal femur of three individuals. Next, the subject-specific musculoskeletal loads were interchanged between the subjects and the resulting changes in bone remodeling of the proximal femur were analyzed. Simulations results were compared to computed tomography (CT) image-based density profiles. The results confirm that the predicted bone density distribution in the proximal femur is drastically influenced by the inclusion of subject-specific loading, i.e. hip contact forces and muscle forces calculated based on gait analysis data and musculoskeletal modeling. This factor dominated the effect of individualized geometry. We conclude that when predicting femoral density distribution in patients, the effect of subject-specific differences in loading conditions of the hip joint and the associated difference in muscle forces needs to be accounted for.
    12/2013; 30C:244-252. DOI:10.1016/j.jmbbm.2013.11.015
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