Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 19104-6010, USA.
Journal of the American Veterinary Medical Association (Impact Factor: 1.56). 10/2006; 229(5):690-3. DOI: 10.2460/javma.229.5.690
Source: PubMed

ABSTRACT To evaluate the effects of diet restriction on development of radiographic evidence of hip joint osteoarthritis in dogs.
Longitudinal cohort study.
48 Labrador Retrievers from 7 litters.
Forty-eight 6-week-old puppies from 7 litters were paired with littermates by sex and weight, and each pairmate was randomly assigned to 1 of 2 groups of 24 dogs each. Starting at 8 weeks of age, 1 group was fed ad libitum (control fed) and the other was fed 25% less (restricted fed) of the same diet for life on a pairwise basis. The dogs' hip joints were radiographed in the standard ventrodorsal hip-extended view at multiple intervals prior to 1 year of age and at annual intervals thereafter on the basis of birth anniversary. A board-certified radiologist unaware of group assignment scored the radiographs for evidence of osteoarthritis.
Prevalence of radiographic evidence of hip joint osteoarthritis in all dogs increased linearly throughout the study, from an overall prevalence of 15% at 2 years to 67% by 14 years. Restricted-fed dogs had lower prevalence and later onset of hip joint osteoarthritis. Median age at first identification of radiographic evidence of hip joint osteoarthritis was significantly lower in the control-fed group (6 years), compared with the restricted-fed group (12 years).
Restricted feeding delayed or prevented development of radiographic signs of hip joint osteoarthritis in this cohort of Labrador Retrievers. Lifetime maintenance of 25% diet restriction delayed onset and reduced severity of hip joint osteoarthritis, thus favorably affecting both duration and quality of life. In addition, the data indicated that development of hip joint osteoarthritis was not bimodal in these dogs but occurred as a continuum throughout life.

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    • "Osteoarthritis (OA) is a chronic, painful, degenerative and inflammatory disease that affects the synovial joints. It is highly prevalent in dogs (Paster et al., 2005; Smith et al., 2006) with 20 % of the canine population over 1 year old presenting various degrees of OA (Aragon et al., 2007; Moreau et al., 2011). This musculoskeletal disease is related to chronic pain, lameness, functional disability and reduced quality of life, leading finally to the loss of joint function and mobility (Henrotin et al., 2005). "
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    ABSTRACT: Osteoarthritis (OA) is a chronic, painful, degenerative and inflammatory disease that affects the synovial joints and leads finally to the loss of mobility. It is highly prevalent in dogs. Nowadays, no cure exists, and the pharmacological treatment is limited to clinical signs alleviation. Some positive beneficial effects have been highlighted with dietary supplements in the course of dog OA. The goals of this narrative review are to summarize the scientific data available in the literature on dietary supplements assessed in dog OA and to discuss some trails about how to improve several aspects of research and issues with dietary supplements, such as bioavailability and dosage regimen. Chondroitin sulphate, glucosamine, undenaturated type II collagen, avocado-soya bean unsaponifiables, curcumin and polyunsaturated fatty acids were studied in dog OA and therefore discussed in the present review. Most of them showed anticatabolic and anti-inflammatory effects. Unfortunately, few data exist concerning their pharmacokinetics. Their bioavailability is low, but new formulations are developed to enhance their gastrointestinal absorption. The clinical relevance of these new formulations compared to native forms should be demonstrated in good clinical trials. Even if further investigations are needed, dietary supplements should be considered in OA management. © 2015 John Wiley & Sons Ltd.
    Journal of Veterinary Pharmacology and Therapeutics 07/2015; DOI:10.1111/jvp.12251 · 1.19 Impact Factor
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    • "In humans, obesity has been identified as a causative factor in the development of knee and hand OA (Grotle et al. 2008; Reijman et al. 2007; Dahaghin et al. 2007). The work of Kealy and colleagues (2000) suggests that obesity may be a risk factor for the development of OA in the dog and this relationship is most convincing for hip OA secondary to dysplasia (Smith et al. 2006). The relationship between obesity and OA in humans and in dogs potentially involves mechanical, metabolic and biochemical factors and has been reviewed (Marshall et al. 2009; Radin et al. 2009). "
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