Polymorphism of the CD14 gene in perennial allergic rhinitis
Allergic diseases have strong genetic backgrounds. Recently, a C-T polymorphism in the promoter region of CD14 has been associated with phenotypes of atopy in some populations. The aim of this study was to investigate the association of CD14/-159 polymorphism with total serum IgE levels and number of positive skin prick tests in Korean population with perennial allergic rhinitis.
Deoxyribonucleic acid obtained from 164 children with perennial allergic rhinitis and 160 healthy controls were typed for the promoter polymorphism of CD14 gene at position -159 by restriction fragment length polymorphism analysis. Genotype frequencies, total serum IgE levels, and the number of positive skin tests for each genotype were compared.
There were no significant differences in the CD14/-159 genotype frequencies between the allergic rhinitis group and the control group. In the skin prick test-positive population, the CC homozygotes were associated with higher serum total IgE levels and greater number of positive skin tests compared with subjects with CT and TT alleles (P<0.05).
The results from the present study suggest that CD14/-159 polymorphism may play a role in the development of perennial allergic rhinitis in Korean children.
Available from: Shekhar Chandra Bisht
- "But it can be predicted that an up-regulation of CD14 expression through MTB might help in pathogenesis of TB by easing immune interactions with mannosylated lipoarabinomannan, which subsequently enhances the production of transforming growth factor (TGF)-β and suppresses the immune response . Furthermore, earlier studies have indicated that CD14 play a critical role in regulation of IgE responses via promotion of Th1 differentiation and suppression of Th2-dependent IgE responses , . Pacheco et al. (2004) pioneered to investigate the association between the TB risk and CD14 −159 C>T polymorphism , thereafter, many studies have been performed to further evaluate the association in different ethnic groups; however the findings were varying and contradictory. "
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ABSTRACT: Cluster of differentiation 14 (CD14) gene is an important component of the human innate immune system and its role in tuberculosis (TB) has been sparsely documented. The enhanced plasma CD14 levels in TB patients as compared to healthy controls are associated with CD14 gene promoter (C-159T) polymorphism. In the past few years, the relationship between CD14 -159 C>T (rs2569190) polymorphism and risk of TB has been reported in various ethnic populations; however, those studies have yielded contradictory results. In this study systemic assessment was done for the published studies based on the association between CD14 -159 C>T polymorphism and TB risk retrieved from PubMed (Medline) and EMBASE search. A total number of 1389 TB cases and 1421 controls were included in this study and meta-analysis was performed to elucidate the association between CD14 -159 C>T polymorphism and its susceptibility towards TB. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele contrast, homozygous comparison, heterozygous comparison, dominant and recessive genetic model. It was found that T allele carrier was significantly associated with increased TB risk (T vs. C: p-value = 0.023; OR = 1.305, 95% CI = 1.038 to 1.640). Similarly, homozygous mutant TT genotype also revealed 1.6 fold increased risk of TB (TT vs. CC; p-value = 0.040; OR = 1.652, 95% CI = 1.023 to 2.667). Additionally, dominant genetic model demonstrated increased risk of developing TB (TT vs. CC+CT: p-value = 0.006; OR = 1.585, 95% CI = 1.142 to 2.201). The study demonstrates that CD14 gene (-159 C>T) polymorphism contributes increased susceptibility for TB. Moreover, this meta-analysis also suggests for future larger studies with stratified case control population and biological characterization for validation studies.
PLoS ONE 05/2013; 8(5):e64747. DOI:10.1371/journal.pone.0064747 · 3.23 Impact Factor
Available from: Guicheng Zhang
- "Buckova et al. (23) 2006 Caucasians exclusively Czech The C allele was associated with positive SPT for mites and moulds with marginal significance. Kang et al. (47) 2006 Koreans Among subjects with SPT+, the CC homozygotes were associated with higher total IgE levels and greater number of SPT+, compared with subjects with CT/TT genotypes. "
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ABSTRACT: This review considers the data from studies analysing associations between the CD14C-159T single nucleotide polymorphism (SNP) and asthmatic phenotypes and discusses the variability of the conclusions. By searching PubMed and EMBASE for articles on CD14C-159T -related population or family-based association studies, 47 were identified up till September 2007. Collectively, the studies reviewed herein consistently showed population differences in frequencies of the alleles of the SNP, with African descent having the highest C allele frequencies, followed by Caucasians and Asians. The T allele of the SNP was associated with increased sCD14 in some studies but not in others. Inconsistently, the C allele, or even occasionally the T allele, was associated with atopic phenotypes in a population subgroup. There are several explanations for these inconsistencies, including lack of power, linkage disequilibrium, gene-gene interactions, population admixture and gene-environment interactions. If the SNP was associated with functional changes to the coded protein and thus modulating susceptibility to allergic disease, its effect may be modest and dependent on other co-existent, ethnicity-specific, genetic or environmental risk factors.
Allergy 12/2008; 63(11):1411-7. DOI:10.1111/j.1398-9995.2008.01804.x · 6.03 Impact Factor
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ABSTRACT: The development of allergic rhinitis (AR) entails a complex interactions between genetic predisposition and environmental exposure to different factors, of which the most important is the implicated allergen. There is a clear hereditary component in AR that has been well corroborated by segregation studies and investigations in twins. From the strictly genetic perspective, it is believed that the disease may be the result of the interaction of different genetic alterations, each of which would contribute a small defect. In recent years considerable attention has focused on the genes that may be implicated in AR. A number of genomic searches have been made yielding different chromosomal associations. Single nucleotide polymorphism of candidate genes (encoding for molecules like chemokines & their receptors, interleukins & their receptors and leukotrienes) have been associated with clinical expression and pathogenesis of AR. Environmental factors (air pollution, house dust, house dust mites) also play an important role in the development of the disease. Further studies are needed to investigate the interactions between genetic and environmental factors that influence the complex trait of allergic diseases.
International Journal of Pharmaceutical Sciences Review and Research 34(1):258-262.
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