Article

Polymorphism of the CD14 gene in perennial allergic rhinitis.

Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital, Korea University College of Medicine, 80 Guro-dong, Guro-gu, Seoul 152-703, Republic of Korea.
International Journal of Pediatric Otorhinolaryngology (impact factor: 1.17). 12/2006; 70(12):2081-5. DOI:10.1016/j.ijporl.2006.07.024 pp.2081-5
Source: PubMed

ABSTRACT Allergic diseases have strong genetic backgrounds. Recently, a C-T polymorphism in the promoter region of CD14 has been associated with phenotypes of atopy in some populations. The aim of this study was to investigate the association of CD14/-159 polymorphism with total serum IgE levels and number of positive skin prick tests in Korean population with perennial allergic rhinitis.
Prospective study.
Deoxyribonucleic acid obtained from 164 children with perennial allergic rhinitis and 160 healthy controls were typed for the promoter polymorphism of CD14 gene at position -159 by restriction fragment length polymorphism analysis. Genotype frequencies, total serum IgE levels, and the number of positive skin tests for each genotype were compared.
There were no significant differences in the CD14/-159 genotype frequencies between the allergic rhinitis group and the control group. In the skin prick test-positive population, the CC homozygotes were associated with higher serum total IgE levels and greater number of positive skin tests compared with subjects with CT and TT alleles (P<0.05).
The results from the present study suggest that CD14/-159 polymorphism may play a role in the development of perennial allergic rhinitis in Korean children.

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    Article: Genetic aspects of allergic rhinitis.
    I Dávila, J Mullol, M Ferrer, J Bartra, A del Cuvillo, J Montoro, I Jáuregui, J Sastre, A Valero
    [show abstract] [hide abstract]
    ABSTRACT: The development of allergic rhinitis entails a complex interaction between genetic predisposition and environmental exposure to different factors, of which the most important is the implicated allergen. There is a clear hereditary component in allergic rhinitis that has been well corroborated by segregation studies and investigations in twins. From the strictly genetic perspective, it is believed that the disease may be the result of the interaction of different genetic alterations, each of which would contribute a small defect. In recent years, considerable attention has focused on the genes that may be implicated in allergic rhinitis. A number of genomic searches have been made, yielding different chromosomal associations--the most repeated being those involving chromosomes 2, 3, 4 and 9. Single-nucleotide polymorphism studies involving genes encoding for molecules implicated in the pathogenesis of allergic rhinitis have also been made. Such molecules comprise chemokines and their receptors, interleukins and their receptors, eosinophil peroxidase and leukotrienes, among others.
    Journal of investigational allergology & clinical immunology: official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 02/2009; 19 Suppl 1:25-31. · 2.27 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

160 healthy controls
 
Allergic diseases
 
C-T polymorphism
 
CC homozygotes
 
CD14 gene
 
CD14/-159 genotype frequencies
 
control group
 
Deoxyribonucleic acid
 
higher serum total IgE levels
 
perennial allergic rhinitis
 
phenotypes
 
populations
 
positive skin prick tests
 
positive skin tests
 
promoter polymorphism
 
promoter region
 
restriction fragment length polymorphism analysis
 
skin prick test-positive population
 
total serum IgE levels
 
TT alleles
 

Hee Joon Kang