Polymorphism of the CD14 gene in perennial allergic rhinitis

Korea University, Sŏul, Seoul, South Korea
International Journal of Pediatric Otorhinolaryngology (Impact Factor: 1.19). 12/2006; 70(12):2081-5. DOI: 10.1016/j.ijporl.2006.07.024
Source: PubMed


Allergic diseases have strong genetic backgrounds. Recently, a C-T polymorphism in the promoter region of CD14 has been associated with phenotypes of atopy in some populations. The aim of this study was to investigate the association of CD14/-159 polymorphism with total serum IgE levels and number of positive skin prick tests in Korean population with perennial allergic rhinitis.
Prospective study.
Deoxyribonucleic acid obtained from 164 children with perennial allergic rhinitis and 160 healthy controls were typed for the promoter polymorphism of CD14 gene at position -159 by restriction fragment length polymorphism analysis. Genotype frequencies, total serum IgE levels, and the number of positive skin tests for each genotype were compared.
There were no significant differences in the CD14/-159 genotype frequencies between the allergic rhinitis group and the control group. In the skin prick test-positive population, the CC homozygotes were associated with higher serum total IgE levels and greater number of positive skin tests compared with subjects with CT and TT alleles (P<0.05).
The results from the present study suggest that CD14/-159 polymorphism may play a role in the development of perennial allergic rhinitis in Korean children.

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    • "But it can be predicted that an up-regulation of CD14 expression through MTB might help in pathogenesis of TB by easing immune interactions with mannosylated lipoarabinomannan, which subsequently enhances the production of transforming growth factor (TGF)-β and suppresses the immune response [33]. Furthermore, earlier studies have indicated that CD14 play a critical role in regulation of IgE responses via promotion of Th1 differentiation and suppression of Th2-dependent IgE responses [34], [35]. Pacheco et al. (2004) pioneered to investigate the association between the TB risk and CD14 −159 C>T polymorphism [18], thereafter, many studies have been performed to further evaluate the association in different ethnic groups; however the findings were varying and contradictory. "
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    ABSTRACT: Cluster of differentiation 14 (CD14) gene is an important component of the human innate immune system and its role in tuberculosis (TB) has been sparsely documented. The enhanced plasma CD14 levels in TB patients as compared to healthy controls are associated with CD14 gene promoter (C-159T) polymorphism. In the past few years, the relationship between CD14 -159 C>T (rs2569190) polymorphism and risk of TB has been reported in various ethnic populations; however, those studies have yielded contradictory results. In this study systemic assessment was done for the published studies based on the association between CD14 -159 C>T polymorphism and TB risk retrieved from PubMed (Medline) and EMBASE search. A total number of 1389 TB cases and 1421 controls were included in this study and meta-analysis was performed to elucidate the association between CD14 -159 C>T polymorphism and its susceptibility towards TB. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele contrast, homozygous comparison, heterozygous comparison, dominant and recessive genetic model. It was found that T allele carrier was significantly associated with increased TB risk (T vs. C: p-value = 0.023; OR = 1.305, 95% CI = 1.038 to 1.640). Similarly, homozygous mutant TT genotype also revealed 1.6 fold increased risk of TB (TT vs. CC; p-value = 0.040; OR = 1.652, 95% CI = 1.023 to 2.667). Additionally, dominant genetic model demonstrated increased risk of developing TB (TT vs. CC+CT: p-value = 0.006; OR = 1.585, 95% CI = 1.142 to 2.201). The study demonstrates that CD14 gene (-159 C>T) polymorphism contributes increased susceptibility for TB. Moreover, this meta-analysis also suggests for future larger studies with stratified case control population and biological characterization for validation studies.
    PLoS ONE 05/2013; 8(5):e64747. DOI:10.1371/journal.pone.0064747 · 3.23 Impact Factor
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    • "Buckova et al. (23) 2006 Caucasians exclusively Czech The C allele was associated with positive SPT for mites and moulds with marginal significance. Kang et al. (47) 2006 Koreans Among subjects with SPT+, the CC homozygotes were associated with higher total IgE levels and greater number of SPT+, compared with subjects with CT/TT genotypes. "
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