Sociodemographic Risk Factors for Autism in a US Metropolitan Area

Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia 30303, USA.
Journal of Autism and Developmental Disorders (Impact Factor: 3.34). 05/2007; 37(4):667-77. DOI: 10.1007/s10803-006-0194-y
Source: PubMed


The present study examined the association between autism and sociodemographic factors, overall and in subgroups of children with autism with and without mental retardation (Autism/MR and Autism/No MR, respectively); the association was further examined in subanalyses by child's source of ascertainment to assess the presence of ascertainment bias. In the main analyses, one marker of higher social class (higher median family income) was significantly associated with autism overall. Both markers of higher social class (higher maternal education and higher median family income) were significantly associated with autism/no MR, but not associated with autism/MR. In the subanalyses, associations with social class varied by ascertainment source. Future studies should consider phenotypic subgroups of children with autism and must consider potential ascertainment bias.

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    • "Recent studies reported that more Caucasian children than African American children were diagnosed on the milder spectrum of ASD, suggesting that cultural differences may confuse the severity of the diagnosis (Baio et al. 2014; Jarquin et al. 2011). African American family beliefs and interpretations of symptoms have been relatively unexplored, despite some ASD investigators noting that the diagnosis may be assigned differentially by the child's culture due to misinterpreted HCP and family interactions (Barton et al. 2012; Bhasin and Schendel 2007; Jarquin et al. 2011; Mandell et al. 2007). The aggregate of these proposed cultural factors reveals a need for exploratory research with African American families to discover their cultural perspectives on caring for children with ASD and the perceptions of family care among ASD professionals. "
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    ABSTRACT: Cultural factors such as health care access and autism spectrum disorder (ASD) symptom interpretations have been proposed as impacting delayed diagnosis and treatment for African American children with ASD. A qualitative study of urban African American families caring for their child with autism was conducted with 24 family members and 28 ASD professionals. Cultural caring meant families protected their child from harm including potential or actual distrustful encounters, and took action for their child and community to optimize their child's health and address the knowledge deficits of ASD within their community. Families and professionals believed cultural influences delayed families' receiving and seeking appropriate health care for the African American child with ASD affecting timely autism diagnosis and treatment.
    Journal of Autism and Developmental Disorders 06/2015; 45(10). DOI:10.1007/s10803-015-2482-x · 3.06 Impact Factor
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    • "However, these levels are considerably lower than in the study areas of California described above (mean value at 25 ± 7.2 ␮g/m 3 in one study and 36.3 ± 6.1 ␮g/m 3 in another study; Becerra et al., 2013; Volk et al., 2013). Furthermore, associations may exist between the socio-economic status at individual or neighborhood level and the risk for neurodevelopmental or behavioral problems (Bhasin & Schendel, 2007; Flouri et al., 2012). "
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    ABSTRACT: Background: Recent studies have reported associations between air pollution exposure and neurodevelopmental disorders in children, but the role of pre- and postnatal exposure has not been elucidated. Aim: We aimed to explore the risk for autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) among children in relation to pre- and postnatal exposure to air pollution from road traffic. Methods: Parents of 3,426 twins born in Stockholm during 1992-2000 were interviewed, when their children were 9 or 12 years old, for symptoms of neurodevelopmental disorders. Residence time-weighted concentrations of particulate matter with a diameter <10 μm (PM10) and nitrogen oxides (NOx) from road traffic were estimated at participants' addresses during pregnancy, the first year, and the ninth year of life using dispersion modeling, controlling for seasonal variation. Multivariate regression models were used to examine the association between air pollution exposure and neurodevelopmental outcomes, adjusting for potential confounding factors. Results: No clear or consistent associations were found between air pollution exposure during any of the three time windows and any of the neurodevelopmental outcomes. For example, a 5-95% difference in exposure to NOx during pregnancy was associated with odds ratios (ORs) of 0.92 (95% confidence interval (CI): 0.44-1.96) and 0.90 (95% CI: 0.58-1.40) for ASD and ADHD respectively. A corresponding range in exposure to PM10 during pregnancy was related to ORs of 1.01 (95% CI: 0.52-1.96) and 1.00 (95% CI: 0.68-1.47) for ASD and ADHD. Conclusions: Our data do not provide support for an association between pre- or postnatal exposure to air pollution from road traffic and neurodevelopmental disorders in children.
    Twin Research and Human Genetics 09/2014; 17(06):1-10. DOI:10.1017/thg.2014.58 · 2.30 Impact Factor
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    • "+veassoc [17] -veassoc [20] -veassoc[17] -veassoc (early cognitive delay ) [55] -veassoc [54] Age Maternal +veassoc [17] [47] +veassoc [17] [21] [29] [47] [56] [57] [58] [59] [60] [61] -veassoc [17] [20] [21] No assoc [46] +veassoc [21] [68] Paternal & maternal +veassoc [17] [56] [58] [61] Only paternal +veassoc [65] +veassoc [58] [62] [63] [64] [65] Maternal & paternal (Denmark, "
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    ABSTRACT: Background: Few common traits separate the mothers of children with autism spectrum disorder (autism) and intellectual disability (ID) from mothers in the general population. Objectives: * To review research on the pre-existing characteristics which differentiate mothers of children with autism and/or ID of unknown cause from each other and from mothers of children without these disabilities * To provide a source for research into the determinants of autism and/or ID, including the role of genetic and modifiable risk factors. Methods: The papers considered for this review resulted from a search of the Medline, Web of Knowledge, Scopus and Google scholar databases. Combinations of the search terms associated with autism and ID, the hypothesised aetiologies of autism and ID and terms associated with traits of mothers of children with autism and/or ID were used. Examples from each of the three groups are ‘autis*, pervasive development disorder* and intellectual disability’, immigra*, migra*, ethnic*, immun*’ and ‘traits, characteristics, mothers, children’. A paper was included in the review if: * It was published in a peer-reviewed journal between 1990 and 2012 inclusive; * It was a full text article in English; * It described new research; * It compared a characteristic of parents or mothers of children with ASD and/or ID with parents or mothers of children without disability or with a population norm; * It assessed characteristics that were pre-existing and not likely to be a result of caring for a child with ASD and/or ID; and * It used methods of ascertainment and measurement of the characteristic(s) of interest that were assessed as unlikely to lead to bias. Results: Overall, autism was correlated positively with socio-economic status (SES), education and age. By contrast, ID had a negative correlation with each of these variables. A reversal was also apparent with parity where lower parity was associated with the autism group and higher with the ID group. More complex associations were found with immigrant status and ethnicity. With the former, excluding Californian population studies, the children of immigrant mothers consistently were associated with increased rates of autism (particularly autism with ID) and lower rates of Mild or moderate ID (mild ID). A reverse scenario was found in California with a higher proportion of mild ID and a lower proportion of autism in the children of immigrant mothers. With ethnicity and with the exception of Asian mothers, there are lower rates of autism and increased rates of ID in the mothers of ethnic minority groups. Asian mothers exhibited an opposite trend. Further, compared to the ID group, many more traits were associated with the mothers of children with autism in the three areas related to immunology, mental health, pregnancy/childbirth and behavioural traits. Possible explanations for these findings are discussed. Conclusions: Further research in these areas may yield more understanding of the genetic and aetiological aspects of autism and ID. In turn, primary and secondary prevention strategies may be refined and/or developed.
    2014 International Meeting for Autism Research; 05/2014
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