Article
Prenatal stress suppresses cell proliferation in the early developing brain.
Department of Psychology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Neuroreport (impact factor:
1.66).
11/2006;
17(14):1515-8.
DOI:10.1097/01.wnr.0000236849.53682.6d
pp.1515-8
Source: PubMed
-
Citations (0)
- Cited In (4)
-
Dataset: Lucassen Korsosi BBR 2012
-
Article: Early-life stress mediated modulation of adult neurogenesis and behavior.
[show abstract] [hide abstract]
ABSTRACT: Early life is a period of unique sensitivity during which experience can confer enduring effects on brain structure and function. During early perinatal life the quality of the surrounding environment and experiences, in particular the parent-child relationship, is associated with emotional and cognitive development later in life. For instance, adverse early-life experience is correlated with an increased vulnerability to develop psychopathologies and aging-related cognitive decline. These are thought to be mediated by acute and long-lasting effects on the, at that time still developing, stress-neuroendocrine and cognitive systems. Adult hippocampal neurogenesis is involved in learning and memory while both regulation of the stress response as well as early-life stress is known to permanently reduce neurogenesis, and to be implicated in these functional deficits. In order to increase our understanding of the influence of the perinatal environment on the long-lasting programming of neurogenesis, we here discuss immediate and lasting effects of various adverse early-life experiences on hippocampal neurogenesis and the associated behavioral alterations. Considering the persistence of these effects, the underlying molecular mechanisms, with focus on the potential epigenetic mechanisms will be discussed as well. Finally, special attention will be paid to the prominent sex differences in early-life stress-induced alterations in neurogenesis.Behavioural brain research 07/2011; 227(2):400-9. · 3.22 Impact Factor -
Dataset: Lucassen Korsosi BBR 2012
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed.
The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual
current impact factor.
Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence
agreement may be applicable.
Keywords
5-bromo-2'-deoxyuridine-positive cells
adverse effects
amygdala
cell proliferation marker 5-bromo-2'-deoxyuridine
dentate gyrus
embryonic stage
hippocampus
limbic brain regions
nonsignificant decrease
nucleus accumbens
postnatal brain development
potential mechanisms
prenatal maternal stress
prenatal stress
prenatal stress induces
significant decrease
