Inflammatory caspases and inflammasomes: master switches of inflammation

Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Epalinges, Switzerland.
Cell Death and Differentiation (Impact Factor: 8.39). 02/2007; 14(1):10-22. DOI: 10.1038/sj.cdd.4402038
Source: PubMed

ABSTRACT Fifteen years have passed since the cloning and characterization of the interleukin-1beta-converting enzyme (ICE/caspase-1), the first identified member of a family of proteases currently known as caspases. Caspase-1 is the prototypical member of a subclass of caspases involved in cytokine maturation termed inflammatory caspases that also include caspase-4 caspase -5, caspase -11 and caspase -12. Efforts to elucidate the molecular mechanisms involved in the activation of these proteases have uncovered an important role for the NLR family members, NALPs, NAIP and IPAF. These proteins promote the assembly of multiprotein complexes termed inflammasomes, which are required for activation of inflammatory caspases. This article will review some evolutionary aspects, biochemical evidences and genetic studies, underlining the role of inflammasomes and inflammatory caspases in innate immunity against pathogens, autoinflammatory syndromes and in the biology of reproduction.

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Available from: Fabio Martinon, Feb 10, 2015
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