Several data indicate a connection between Chlamydophila pneumoniae infection and asthma. Although C. pneumoniae is a common cause of infection, not all infected patients develop asthma. This suggests that certain individuals may be genetically predisposed to the chronic effects of C. pneumoniae infection on airway functions. We investigated the possible modifying effect of different polymorphisms on C. pneumoniae infection and on the susceptibility to asthma in 318 children, among those 144 had asthma and 174 had no asthmatic symptoms. C. pneumoniae-specific antibodies were measured by ELISA. Tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and RANTES (regulated on activation normal T cell expressed and secreted) genotypes were determined by PCR-restriction fragment length polymorphism (RFLP). There were no significant differences in the percentage of children positive for C. pneumoniae-specific antibodies between cases and controls. None of the genotypes was associated with altered susceptibility to C. pneumoniae infection. Among asthmatic children carrying the TNFalpha -308A allele, there were significantly more patients positive for C. pneumoniae-specific IgG, than among control children carrying the same allele (20.1% versus 9.2% of asthmatic versus control children, respectively; p = 0.002; odds ratio = 3.52 (1.52-7.53); p = 0.005). This study indicates the possible roles of polymorphisms in the immune system in the susceptibility to asthma in children infected with C. pneumoniae.
"Several reports found associations between the –308A allele and asthma. An example for the gene–environmental interaction in asthma is, that children positive for Chlamydophila pneumoniae-specific IgG carrying the TNF À308A allele have considerably higher risk of developing asthma than children with similar infection status carrying wild-type genotypes (Tölgyesi et al., 2006). Nicolae et al. (2005) conducted a genome-wide screen of families who participated in the Collaborative Study on the Genetics of Asthma. "
[Show abstract][Hide abstract] ABSTRACT: Pharmacogenomics, a fascinating, emerging area of biomedical research is strongly influenced by growing availability of genomic databases, high-throughput genomic technologies, bioinformatic tools and artificial computational modelling approaches. One main area of pharmacogenomics is the discovery of new drugs and drug targets with molecular genetic, genomic or even bioinformatic methods; the other is the study of how genomic differences influence the variability in patients' responses to drugs. From a genetic point of view, asthma is multifactorial, which means that the susceptibility to the disease is determined by interactions between multiple genes, and involves important non-genetic factors such as the environment for their expression. In this review, we summarize collective evidence from linkage and association studies that have consistently reported suggestive linkage or association of asthma or its associated phenotypes to polymorphic markers and single nucleotide polymorphisms in selected chromosomes. Genes that have been found implicated in the disease are potential new drug targets and several pharmacological investigations are underway to utilize these new discoveries. Next, we will focus on the inter-individual variability in anti-asthmatic drug responses and review the recent results in this topic.
British Journal of Pharmacology 05/2008; 153(8):1602-14. DOI:10.1038/bjp.2008.55 · 4.84 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Chlamydia pneumoniae infection might play a role in the pathology of asthma, but its role in infantile asthma remains obscure. The presence of Chlamydia pneumoniae was serologically determined in wheezing infants who were then re-examined 1-year later to determine whether or not asthma is associated with this type of infection. Wheezing infants progressed to asthma more frequently after infection with Chlamydia pneumoniae than those who were not infected. These findings suggested that Chlamydia pneumoniae infection triggers asthma in wheezy infants.
Journal of Asthma 10/2007; 44(7):565-8. DOI:10.1080/02770900701537115 · 1.80 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The respiratory sequelae of pulmonary infections with MP and CP are very diverse. Some of them are associated with the development of a non-specific acute pulmonary complication (e.g., empyema, pleurisy, pneumomediastinum). In contrast, others appear to be associated with a particular tropism of these bacteria for the respiratory tract.Among these, chronic cough deserves to be considered apart. The onset of asthmatic manifestations, exacerbation of previously existing asthma, and perpetuation of inflammatory phenomena appear to occur in children who are predisposed. The pathophysiology of associated bronchial hyperreactivity brings on a cascade of inflammatory mechanisms which include a number of cytokines. Use of macrolides for a prolonged period is justified in certain cases with chronic cough or with asthma that is poorly controlled with standard therapy.
Revue Française d Allergologie et d Immunologie Clinique 11/2007; DOI:10.1016/j.allerg.2007.08.002 · 0.24 Impact Factor
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