Tachykinins and excitotoxicity in cerebellar granule cells.
ABSTRACT The tachykinins represent an important group of neuropeptides that are widely distributed both in the central and peripheral nervous system where they perform several functions connected with neuronal modulation, often in synergy with glutamate excitatory transmission. While a great deal of data is available on their distribution and many studies have been performed by molecular, biochemical, and immunohistochemical techniques, much less is known about their physiological role, in particular in the cerebellum. This review is an attempt to summarize the diverse evidence suggesting a role for tachykinins in cerebellar granule neurons.
Conference Paper: Quality issues in database reverse engineering: an overview[Show abstract] [Hide abstract]
ABSTRACT: Database reverse engineering is the part of system maintenance work that produces a sufficient understanding of an existing database and its application domain to allow appropriate changes to be made. It is often difficult to obtain a good conceptual understanding of an old and ill-designed database, especially when there is a lack of documentation. Database reverse engineering attempts to provide solutions for these problems. Three quality issues regarding reverse engineering of existing databases are discussed: (1) the method of database design chosen to serve as the basis for reverse engineering, (2) thoroughness of domain semantics acquisition, and (3) performance evaluation criteria. These quality issues are important for any database reverse engineering method in order for it to perform at a high level of automation, and to obtain a conceptual schema that is semantically rich and correctEngineering Management Conference, 1995. 'Global Engineering Management: Emerging Trends in the Asia Pacific'., Proceedings of 1995 IEEE Annual International; 07/1995
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ABSTRACT: Research on the cerebellum is evolving rapidly. The exquisiteness of the cerebellar circuitry with a unique geometric arrangement has fascinated researchers from numerous disciplines. The painstaking works of pioneers of these last two centuries, such as Rolando, Flourens, Luciani, Babinski, Holmes, Cajal, Larsell, or Eccles, still exert a strong influence in the way we approach cerebellar functions. Advances in genetic studies, detailed molecular and cellular analyses, profusion of brain imaging techniques, emergence of behavioral assessments, and reshaping of models of cerebellar function are generating an immense amount of knowledge. Simultaneously, a better definition of cerebellar disorders encountered in the clinic is emerging. The essentials of a trans-disciplinary blending are expanding. The analysis of the literature published these last two decades indicates that the gaps between domains of research are vanishing. The launch of the society for research on the cerebellum (SRC) illustrates how cerebellar research is burgeoning. This special issue gathers the contributions of the inaugural conference of the SRC dedicated to the mechanisms of cerebellar function. Contributions were brought together around five themes: (1) cerebellar development, death, and regeneration; (2) cerebellar circuitry: processing and function; (3) mechanisms of cerebellar plasticity and learning; (4) cerebellar function: timing, prediction, and/or coordination?; (5) anatomical and disease perspectives on cerebellar function.The Cerebellum 11/2008; 7(4):505-16. DOI:10.1007/s12311-008-0063-7 · 2.86 Impact Factor
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ABSTRACT: The classic theorem of Fitts (1954) asserts that the combined effects of movement amplitude and target width (index of difficulty: ID) define movement times (MTs) for goal-directed reaches. Moreover, Fitts' theorem states that reaches yielding the same ID produce equivalent MTs regardless of the response's amplitude and width combination. However, most work providing direct support for Fitts' theorem has employed short movement amplitudes and small target widths. Thus, no direct evidence supports the unitary nature of MT/ID relations across a range of amplitudes and widths used in contemporary studies of goal-directed reaching. To that end, we contrasted MT/ID relations for discrete reaches equated for movement ID but differing with respect to their amplitude (15.5, 19, 25.5, and 38 cm) and width (2, 3, 4, and 5 cm) requirements. Results show that amplitude and width manipulations yielded robust linear MT/ID relations; however, the slope of the MT/ID function was markedly steeper in the former (amplitude=92 ms; width=13 ms). Such findings indicate that the constituent elements of movement ID are dissociable and that the fixed parameter nature of Fitts' theorem cannot be applied to a continuous range of veridical movement amplitudes and target widths.Canadian Journal of Experimental Psychology 07/2011; 65(4):259-68. DOI:10.1037/a0023618 · 1.02 Impact Factor