Article

Triclosan in Plasma and Milk from Swedish Nursing Mothers and Their Exposure via Personal Care Products

Stockholm University, Tukholma, Stockholm, Sweden
Science of The Total Environment (Impact Factor: 4.1). 01/2007; 372(1):87-93. DOI: 10.1016/j.scitotenv.2006.08.007
Source: PubMed

ABSTRACT The bactericide triclosan is commonly used in e.g. plastics, textiles and health care products. In vitro studies on rat and human biological systems indicate that triclosan might exert adverse effects in humans. Triclosan has previously been found in human plasma and milk, but neither the primary source of human exposure nor the efficiency of triclosan transfer to human milk is known. In this study, plasma and milk were sampled from 36 mothers and analyzed for triclosan. Scrutinization of the women's personal care products revealed that nine of the mothers used toothpaste, deodorant or soap containing triclosan. Triclosan and/or its metabolites were omnipresent in the analyzed plasma and milk. The concentrations were higher in both plasma and milk from the mothers who used personal care products containing triclosan than in the mothers who did not. This demonstrated that personal care products containing triclosan were the dominant, but not the only, source of systemic exposure to triclosan. The concentrations were significantly higher in plasma than in milk, indicating that infant exposure to triclosan via breast milk is much less than the dose in the mother.

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    • "A study showed a 70 mM TCS cream underwent 10% absorption into human skin, showing absorption into the skin in the millimolar range (Queckenberg, et al. 2010). TCS is detectable in both blood and milk of lactating mothers (Allmyr, et al. 2006). "
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    • "TCS has been detected in water and sediments (Zhang et al., 2013; Pintado-Herrera et al., 2014) and in human workplaces and house dust (Canosa et al., 2007; Geens et al., 2009). A number of studies have revealed the presence of TCS in human tissues, such as the blood (Allmyr et al., 2006, 2008), adipose tissue, liver tissue, and brain tissue (Geens et al., 2012), as well as in breast milk (Allmyr et al., 2006; Toms et al., 2011) and urine (Kim et al., 2011; Mortensen et al., 2014). There are inconsistent data concerning the bioaccumulation of TCS in living organisms. "
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