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CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.

Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy.
The Journal of Immunology (Impact Factor: 5.36). 11/2006; 177(8):5290-5. DOI: 10.4049/jimmunol.177.8.5290
Source: PubMed

ABSTRACT Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.

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