Menopause and determinants of quality of life in women at midlife and beyond: The Study of Health in Pomerania (SHIP)

Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Clinical Research Center of Women's Health, Berlin, Germany.
Menopause (Impact Factor: 3.36). 12/2006; 14(1):123-34. DOI: 10.1097/01.gme.0000227860.58097.e9
Source: PubMed


Determinants of quality of life (QoL) in pre- and postmenopausal women including nonhormonal modulators of QoL in adult women are not well understood; there is an ongoing controversy about the impact of menopause on health-related QoL. We investigated the extent to which diverse mental and physical symptoms are associated with (a) menopausal status; (b) sociodemographic, psychosocial, and lifestyle factors; and (c) menopausal hormone therapy (MHT) in adult women after the German reunification in a region of the former German Democratic Republic.
The Study of Health in Pomerania is a cross-sectional, population-based survey. Computer-based structured interviews and self-administered questionnaires were used to capture QoL (Zerssen Symptom List) and sociodemographic parameters, psychosocial, and lifestyle indicators (age, socioeconomic status, abuse, social support, nutrition, body mass index, self-rated health, chronic diseases, and use of MHT) in 1,119 pre- and postmenopausal women with an intact uterus.
Analyses suggest that menopausal status was not associated with QoL. MHT was associated with physical, mental, and gastrointestinal symptoms. Age was a significant predictor for cardiopulmonary symptoms and sensory impairment. The relationship between age and both physical and mental complaints was inverse as was the relationship between age and both mood and gastrointestinal symptoms. Age, socioeconomic status, physical and sexual abuse, perceived social support, nutrition, body mass index, self-rated health, chronic diseases, and MHT modulated QoL.
Our findings do not support the hypothesis that QoL is reduced after menopause. Differences between pre- and postmenopausal women can be explained by sociodemographic, psychosocial, and lifestyle factors.

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    • "for menopausal symptoms (Blumel et al., 2000; Chedraui , San Miguel, & Avila, 2009; Schwarz et al., 2007), comorbidities (Baumeister, Balke, & Harter, 2005), and/ or effects of normal aging (Motl & McAuley, 2010; van Londen et al., 2013). The purpose of this focus group study was to explore survivors' recollection of the conversation with the medical oncologist about starting AET, experiences with AET-related symptoms, AET-related symptom management , challenges to taking AET, and views about how AET-related symptoms might be better managed. "
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    • "Sanfélix-Genovés et al. [7] identified osteoporotic vertebral fractures to be associated with significantly lowered physical HRQL. Schwarz et al. [8] used a multi-morbidity index including hypertension, unspecified chronic back pain, arthrosis, varicosis, elevated blood lipids, migraine, thyroid disease, osteoporosis, arthritis and diabetes mellitus. Multi-morbidity was linearly associated with pain and gastrointestinal symptoms. "
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    Health and Quality of Life Outcomes 11/2011; 9(1):97. DOI:10.1186/1477-7525-9-97 · 2.12 Impact Factor
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    • "We found the physical and psychosocial quality of life scores in women who had income satisfaction to be lower than women in other group. This result was confirmed in several studies[13],[28],[37] but other studies have not shown association between income and QOL.[27],[29],[31] High income level may be increased by more access to health care centers and lead to a health promotion. "
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