Article

Role of cytokines in head and neck squamous cell carcinoma.

University of Schleswig-Holstein Campus Lübeck, Department of Otorhinolaryngology, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Expert Review of Anti-infective Therapy (impact factor: 2.65). 10/2006; 6(9):1195-203. DOI:10.1586/14737140.6.9.1195
Source: PubMed

ABSTRACT Head and neck squamous cell carcinoma is one of the most frequent cancers and standard treatment has only marginally improved the 5-year survival rate of patients with this disease in the last few decades. It is supposed that cytokine alterations in immune, inflammatory and angiogenetic regulatory routes within the head and neck squamous cell carcinoma microenvironment play a critical role in tumor aggressiveness, its response to chemo- and radiation therapies, as well as the development of immune escape mechanisms.

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Keywords

5-year survival rate
 
angiogenetic regulatory routes
 
chemo-
 
cytokine alterations
 
frequent cancers
 
last
 
neck squamous cell carcinoma
 
neck squamous cell carcinoma microenvironment
 
radiation therapies
 
tumor aggressiveness