Article

Infections of the central nervous system by melanized fungi: a review of cases presented between 1999 and 2004

Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdamo, North Holland, Netherlands
Mycoses (Impact Factor: 1.81). 03/2004; 47(1-2):4-13. DOI: 10.1046/j.1439-0507.2003.00956.x
Source: PubMed

ABSTRACT Several types of infections of the central nervous system by melanized fungi can be distinguished: (a) single-organ infection of the cerebrum, (b) extension into the cerebrum from adjacent cavities, (c) fungal presence in the cerebrospinal fluid, or (d) meningitis. The fungal order Chaetothyriales (containing Exophiala-like black yeasts and relatives) is particularly rich in fungi causing cerebral infections. Cases by the main agents, Cladophialophora bantiana, Exophiala dermatitidis, and Ramichloridium mackenziei, published during the last 5 years are reviewed. Most of these infections prove to be fatal. Resection of the lesions in combination with antimycotic therapy may reduce mortality.

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