Article

[Analysis of the non-Hodgkin lymphoma's clinic and blood marrow cytogenetics].

Department of Hematology, the Affiliated Changzhou Second People's Hospital, Nanjing Medical University, Changzhou, Jiangsu, 213003 PR China.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 11/2006; 23(5):568-70.
Source: PubMed

ABSTRACT To analyze the relationship among cytogenetics, hematopathology, morphology, clinic tumor index and prognosis of the non-Hodgkin lymphoma(NHL) patients.
Cytogenetics analysis of bone marrow cells was performed by direct method and 24 h culture method in 20 cases of NHL. Serous P53 protein was detected in all patients.
Out of the twenty NHL patients, eight had bone marrow infiltration, and nine were found with abnormal karyotype: three were chromosome number abnormalities, one was t(14,18)(q32;q21), one was 14q+, two were t(8;14)(q24;q32), two were t(8;14)(q24;q32) with additional changes of chromosome. The serous P53 protein of patients with abnormal karyotype was significantly higher than that with normal karyotype.
t(8;14) (q24;q32) is the most classic translocation in NHL, The patients with this karyotype have worse prognosis. The increase of mutant serous P53 relates to abnormal karyotype, and the patients with high mutant P53 level in serum also have worse prognosis.

0 0
 · 
0 Bookmarks
 · 
18 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

24 h culture method
 
abnormal karyotype
 
additional changes
 
bone marrow cells
 
clinic tumor index
 
cytogenetics
 
Cytogenetics analysis
 
mutant P53 level
 
mutant serous P53 relates
 
non-Hodgkin lymphoma(NHL)
 
normal karyotype
 
patients
 
serous P53 protein
 
twenty NHL patients