Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol.
ABSTRACT To examine the safety and efficacy of a chitosan dietary supplement on body composition under free-living conditions.
In a randomized, double-blinded, placebo-controlled dietary intervention protocol, subjects were assigned to a treatment group (TRT), a placebo group (PLA) and a control group (CTL).
A total of 150 overweight adults enrolled; 134 (89.3%) completed the study; 111 (82.8%) were women who were similarly distributed in the three groups.
The TRT group took six 500 mg chitosan capsules per day and both TRT and PLA groups wore pedometers during their waking hours and recorded daily step totals. The CTL group followed weight loss programs of their choice, and took the same baseline and ending tests.
Outcome measures were Dual Energy X-ray Absorptiometry tests, fasting blood chemistries, and self-reported daily activity levels and caloric intakes.
Compared to CTL, the TRT group lost more weight (-2.8 lbs vs. +0.8 lbs, p < 0.001) and fat mass (-2.6 lbs vs. +0.1 lbs, p = 0.006). Compared to PLA, the TRT group lost more weight (-2.8 lbs. vs. -0.6 lbs, p = 0.03), % fat (-0.8% vs. +0.4%, p = 0.003), fat mass (-2.6 lbs vs. +0.6 lbs, p = 0.001) and had a greater body composition improvement index (BCI) (+2.4 lbs vs. -1.9 lbs, p = 0.002).
These data provide evidence for the efficacy of a chitosan compound to facilitate the depletion of excess body fat under free-living conditions with minimal loss of fat-free or lean body mass.
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ABSTRACT: Perfluorooctanoic acid (PFOA) is one of the most commonly used perfluorinated compounds. Being a persistent environmental pollutant, it can accumulate in human tissues via various exposure routes. The aim of the current study was to evaluate the protective role of carboxymethyl chitosan (CMC) against PFOA-induced toxicity at the genetic and protein levels in Nile tilapia using the biochemistry analysis, SDS-PAGE electrophoresis, comet assay and RFLP-PCR methods. The results indicated that exposure to PFOA in water (30 mg/L) for 30 days resulted in significant increase in ALT, AST, BUN, createnine accompanied with a significant decrease in total protein and albumin. PFOA also increased DNA damage in electrophoresis condition and induced DNA and protein polymorphic band in compared to control fish. CMC alone at 1 and 2% (W/W) in fish diets did not induce any alterations in the biochemical parameters, DNA or protein levels compared to control group. Furthermore, CMC succeeded to decrease the toxicity of PFOA in a dose dependent manner. It could be concluded that PFOA induced genotoxicity and oxidative stress in fish similar to those reported in mammals. CMC is a promise candidate and has a protective effect against-PFOA induced in vivo DNA damage and protein alteration in Nile tilapia. This effect might be attributable to its ability to decrease intracellular ROS and its antioxidant properties.05/2014; DOI:10.1016/j.jssas.2014.04.005
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ABSTRACT: With the development of cancer immunotherapy, cancer vaccine has become a novel modality for cancer treatment, and the important role of adjuvant has been realized recently. Chitin, chitosan, and their derivatives have shown their advantages as adjuvants for cancer vaccine. In this paper, the adjuvant properties of chitin and chitosan were discussed, and some detailed information about glycated chitosan and chitosan nanoparticles was also presented to illustrate the trend for future development.Clinical and Developmental Immunology 03/2013; 2013:387023. DOI:10.1155/2013/387023 · 2.93 Impact Factor
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ABSTRACT: HS219 (40 mg chitosan-loaded chewing gum) is designed to bind salivary phosphorus as an add-on to available phosphorus binders. We performed a randomized, placebo-controlled, double-blind study to evaluate the efficacy and safety of HS219 in hemodialysis (HD) patients with hyperphosphatemia as an add-on to phosphorus binders.BMC Nephrology 06/2014; 15(1):98. DOI:10.1186/1471-2369-15-98 · 1.52 Impact FactorThis article is viewable in ResearchGate's enriched formatRG Format enables you to read in context with side-by-side figures, citations, and feedback from experts in your field.