Boffetta PEpidemiology of peritoneal mesothelioma: a review. Ann Oncol 18: 985-990

International Agency for Research on Cancer, Lyon, France.
Annals of Oncology (Impact Factor: 7.04). 07/2007; 18(6):985-90. DOI: 10.1093/annonc/mdl345
Source: PubMed


The epidemiology of peritoneal mesothelioma is complicated by possible geographic and temporal variations in diagnostic practices. The incidence rates in industrialized countries range between 0.5 and three cases per million in men and between 0.2 and two cases per million in women. Exposure to asbestos is the main known cause of peritoneal mesothelioma. Results on peritoneal mesothelioma have been reported for 34 cohorts exposed to asbestos, among which a strong correlation was present between the percentages of deaths from pleural and peritoneal mesothelioma (correlation coefficient 0.8, P < 0.0001). Studies of workers exposed only or predominantly to chrysotile asbestos resulted in a lower proportion of total deaths from peritoneal mesothelioma than studies of workers exposed to amphibole or mixed type of asbestos. Cases of peritoneal mesothelioma have also been reported following exposure to erionite and Thorotrast, providing further evidence of common etiological factors with the pleural form of the disease. The role of other suspected risk factors, such as simian virus 40 infection and genetic predisposition, is unclear at present. Control of asbestos exposure remains the main approach to prevent peritoneal mesothelioma.

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    • "Malignant peritoneal mesothelioma is a rare cancer with poor patient survival. The incidence of peritoneal mesothelioma worldwide is approximately one case in a population of 4-5 million,[1] with an incidence of all mesotheliomas being 1 in 1 million.[1] However, the incidence rates in industrialized countries are greater and range between 0.5 and 3 cases per million in men and between 0.2 and 2 cases per million in women.[1] "
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    ABSTRACT: This report highlights that pleural and peritoneal mesothelioma can occur without direct asbestos exposure as was seen in our young patient. The patient had indirect exposure for as short as 3 months as a child, 15 years earlier, when she was residing with her miner father in the district of Jharia, Jharkhand, which is an asbestos-rich mining area in eastern India. The patient presented with chest pain and breathlessness. Chest X-ray showed opaque right hemithorax. Typical contrast- computed tomography (CECT) enhanced radiological features included nodular, soft-tissue attenuation and homogenously enhancing rind-like mass causing scalloping of the underlying lung and liver. Similar lesions were also found involving the pelvis. Diagnosis of malignant mesothelioma was confirmed on lung biopsy. Under-reporting of exposure is usual because it is unrecognized by both patients and investigators.
    Journal of Clinical Imaging Science 06/2014; 4(1):35. DOI:10.4103/2156-7514.135662
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    • "While only perhaps 10–20% of pleural mesothelioma cases in the past decade are reportedly due to causes other than asbestos exposure (Sporn and Roggli, 2004), the risk factors for peritoneal mesothelioma are far more diverse, with less than half of the cases in recent case series explained by heavy amphibole exposures (Neumann et al., 2001; Hillard et al., 2003; Weill et al., 2004; Reid et al., 2005; Bofetta and Stayner, 2006; Bofetta, 2007; Larson et al., 2007; Magnani et al., 2007; Gibbs and Berry, 2008). Pericardial mesothelioma is far less common than the pleural and peritoneal forms and has no strong or consistent association with asbestos exposure (Papi et al., 2005; Luk et al., 2008). "
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    ABSTRACT: The diagnosis of mesothelioma is not always straightforward, despite known immunohistochemical markers and other diagnostic techniques. One reason for the difficulty is that extrapleural tumors resembling mesothelioma may have several possible etiologies, especially in cases with no meaningful history of amphibole asbestos exposure. When the diagnosis of mesothelioma is based on histologic features alone, primary mesotheliomas may resemble various primary or metastatic cancers that have directly invaded the serosal membranes. Some of these metastatic malignancies, particularly carcinomas and sarcomas of the pleura, pericardium and peritoneum, may undergo desmoplastic reaction in the pleura, thereby mimicking mesothelioma, rather than the primary tumor. Encasement of the lung by direct spread or metastasis, termed pseudomesotheliomatous spread, occurs with several other primary cancer types, including certain late-stage tumors from genetic cancer syndromes exhibiting chromosomal instability. Although immunohistochemical staining patterns differentiate most carcinomas, lymphomas, and mestastatic sarcomas from mesotheliomas, specific genetic markers in tumor or somatic tissues have been recently identified that may also distinguish these tumor types from asbestos-related mesothelioma. A registry for genetic screening of mesothelioma cases would help lead to improvements in diagnostic criteria, prognostic accuracy and treatment efficacy, as well as improved estimates of primary mesothelioma incidence and of background rates of cancers unrelated to asbestos that might be otherwise mistaken for mesothelioma. This information would also help better define the dose-response relationships for mesothelioma and asbestos exposure, as well as other risk factors for mesothelioma and other mesenchymal or advanced metastatic tumors that may be indistinguishable by histology and staining characteristics.
    Frontiers in Genetics 05/2014; 5:151. DOI:10.3389/fgene.2014.00151
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    • "Only 20–33% of all mesotheliomas arise from the peritoneum itself. Each year, only approximately 250 to 500 new cases of peritoneal mesothelioma were diagnosed in the United States [3, 7, 8]. It can occur at any age but is more common in 50–69-year-old men due to occupational exposure of crocidolite variety of asbestos. "
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    ABSTRACT: We report a case of synchronous primary colonic adenocarcinoma and malignant mesothelioma. A 61-year-old male presented with a six-month history of fatigue and weight loss. An abdominal computed tomography (CT) scan showed a 5.8 cm partially obstructing mass in the cecum with ascites and peritoneal thickening. A biopsy of the large mass showed an adenocarcinoma. Because the patient was clinically thought to be a T4 colon carcinoma with peritoneal metastatic lesions (M1), prior to initiating chemotherapy, a debulking right hemicolectomy was performed. Resection of the colon and ileum revealed a T3N0 colonic mucinous adenocarcinoma and concurrent diffuse malignant peritoneal mesothelioma. Presenting synchronous colonic and peritoneal mesothelial primary malignancies are exceedingly rare but must be considered to prevent incorrect clinical staging.
    05/2014; 2014(3):838506. DOI:10.1155/2014/838506
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