Article

Melatonin treatment in adolescents with delayed sleep phase syndrome

Tel Aviv University, Tell Afif, Tel Aviv, Israel
Clinical Pediatrics (Impact Factor: 1.26). 12/2006; 45(9):809-18. DOI: 10.1177/0009922806294218
Source: PubMed

ABSTRACT This retrospective study describes the effects of long-term treatment with melatonin in 33 adolescents (age range, 10-18 years) with delayed sleep phase syndrome (DSPS). Patients were treated with oral melatonin, 3 to 5 mg/day for an average period of 6 months. During the treatment, sleep onset was advanced and sleep duration was longer. Treatment was also associated with a decrease in the proportion of patients reporting school difficulties. No adverse effects of melatonin were noted. This study indicates that long-term treatment with melatonin can be beneficial for adolescents with DSPS in terms of sleep-wake schedule and school performance.

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