Modeling of chromosome motility during mitosis.

Department of Biomedical Engineering, University of Minnesota, 7-132 Hasselmo Hall, 312 Church Street S.E., Minneapolis, Minnesota 55455, USA.
Current Opinion in Cell Biology (Impact Factor: 8.74). 01/2007; 18(6):639-47. DOI: 10.1016/
Source: PubMed

ABSTRACT Chromosome motility is a highly regulated and complex process that ultimately achieves proper segregation of the replicated genome. Recent modeling studies provide a computational framework for investigating how microtubule assembly dynamics, motor protein activity and mitotic spindle mechanical properties are integrated to drive chromosome motility. Among other things, these studies show that metaphase chromosome oscillations can be explained by a range of assumptions, and that non-oscillatory states can be achieved with modest changes to the model parameters. In addition, recent microscopy studies provide new insight into the nature of the coupling between force on the kinetochore and kinetochore-microtubule assembly/disassembly. Together, these studies facilitate advancement toward a unified model that quantitatively predicts chromosome motility.

  • Source
  • [Show abstract] [Hide abstract]
    ABSTRACT: The Hungarian Telecom Company wants to invest a lot into the new telephone exchanges in the future. Of course, the new exchanges require also new power systems. It is very important to assure the conditions of the high-quality power supplies. The technical requirements should be worked out, new types of the equipment should be examined and the right maintenance should be organised.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Mitosis is the process by which the genome is segregated to form two identical daughter cells during cell division. The process of cell division is essential to the maintenance of every form of life. However, a detailed quantitative understanding of mitosis has been difficult owing to the complexity of the process. Indeed, it has been long recognized that, because of the complexity of the molecules involved, their dynamics and their properties, the mitotic events that mediate the segregation of the genome into daughter nuclei cannot be fully understood without the contribution of mathematical/quantitative modelling. Here, we provide an overview of mitosis and describe the dynamic and mechanical properties of the mitotic apparatus. We then discuss several quantitative models that emerged in the past decades and made an impact on our understanding of specific aspects of mitosis, including the motility of the chromosomes within the mitotic spindle during metaphase and anaphase, the maintenance of spindle length during metaphase and the switch to spindle elongation that occurs during anaphase.
    Interface focus: a theme supplement of Journal of the Royal Society interface 06/2014; 4(3):20130073. DOI:10.1098/rsfs.2013.0073 · 3.12 Impact Factor


Available from