Article

Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products.

Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, MA 02215, USA
Organic Letters (Impact Factor: 6.14). 11/2006; 8(22):5169-71. DOI: 10.1021/ol062233m
Source: PubMed

ABSTRACT Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products are reported. Key steps involve copper-mediated, enantioselective oxidative dearomatization to prepare the azaphilone core and olefin cross-metathesis for side-chain installation. [reaction: see text]

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