Keeping transcriptional activators under control.

Department of Internal Medicine , University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, USA.
Cell (Impact Factor: 33.12). 11/2006; 127(2):261-4. DOI: 10.1016/j.cell.2006.10.002
Source: PubMed

ABSTRACT Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this process.

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