Article

Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy.

Developmental Endoscopy Unit, Charlton 8-200, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Gastrointestinal Endoscopy (impact factor: 4.88). 12/2006; 64(5):808-12. DOI:10.1016/j.gie.2006.04.038 pp.808-12
Source: PubMed

ABSTRACT Iatrogenic inflammation of the porcine uterine horn may serve as an in vivo appendicitis model for the development of endoscopic transgastric appendectomy.
Five female pigs.
Animal study.
General anesthesia.
Anatomical appearance and technical feasibility.
Three pigs were used to identify an injectable material that would inflame the uterine horn, and 2 pigs were used for a pilot appendectomy. Three types of materials were individually injected into the bilateral uterine horns, and the ideal material to inflame the uterine horn was injected into the right uterine horn for the last 2 pigs. After 24 hours, the injected uterine horns of the first 3 pigs were assessed and a pilot appendectomy was performed in the last 2 pigs.
Ethanolamine oleate (EO) injected uterine horns demonstrated similarities to the inflamed human appendix. Simulations of the appendectomy were successfully performed by using the EO model.
Suboptimal existing tools.
This preliminary study demonstrated the technical feasibility to create a model for acute appendicitis by using the porcine uterine horn and transgastric appendectomy.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

2 pigs
 
acute appendicitis
 
Animal study
 
bilateral uterine horns
 
endoscopic transgastric appendectomy
 
Ethanolamine oleate
 
female pigs
 
first 3 pigs
 
Iatrogenic inflammation
 
ideal material
 
inflamed human appendix
 
injected uterine horns
 
last 2 pigs
 
porcine uterine horn
 
preliminary study
 
technical feasibility
 
transgastric appendectomy
 
uterine horn
 
uterine horns
 
vivo appendicitis model