The Intestinal Microvasculature as a Therapeutic Target in Inflammatory Bowel Disease

Division of Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Annals of the New York Academy of Sciences (Impact Factor: 4.31). 09/2006; 1072(1):78-97. DOI: 10.1196/annals.1326.003
Source: PubMed

ABSTRACT Chronic inflammation is a complex biologic process which involves immune as well as non-immune cells including the microvasculature and its endothelial lining. Growing evidence suggests that the microvasculature plays an integral role in the pathophysiology of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The microvasculature contributes to chronic inflammation through altered leukocyte recruitment, impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of IBD microvascular biology represent therapeutic targets that are currently undergoing investigation.

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    • "The microcirculation and its lining endothelium play a central role in the initiation and perpetuation of the inflammatory response, as well as in tissue remodelling during chronic inflammation. Investigation into the cellular and molecular mechanisms in human inflammatory bowel disease , such as ulcerative colitis, has demonstrated a central role for the intestinal microvascular endothelium in both normal mucosal immunity and the dysregulated chronic inflammation that characterizes IBD [10]. There is now increasing evidence to suggest that neovascularization in response to tissue damage may involve bone marrow-derived endothelial progenitor cells [14]. "
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