Baclofen-associated encephalopathy in a hemodialysis patient with hiccups

Servicio de Nefrología y Trasplante Renal, Hospital Clinic, Barcelona.
Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia (Impact Factor: 1.22). 02/2006; 26(4):486-8.
Source: PubMed

ABSTRACT Baclofen is a centrally acting gamma-ammino butyric acid agonist that is used like muscular relaxant in disorders with spasticity and intractable hiccups. Although encouraging and safe results were provided 5 mg/day in hemodialysis patients, his pharmacokinetic and pharmacodinamic properties are not well known in end stage renal disease. We present here the case of a hemodialysis patient with intractable hiccups who developed baclofen-associated encephalopathy with this recommended dose.

Download full-text


Available from: Luis F Quintana, Sep 26, 2015
135 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Intractable singultus is a rare but significantly disruptive clinical phenomenon that often accompanies other diseases but can present in isolation due entirely to intracranial pathology. We report a case of intractable singultus that improved after microvascular decompression and present a comprehensive review of singultus by discussing its similarity to other cases of microvascular decompression, its history and etiology, and its evolutionary basis. The patient exhibited intractable singultus for 15 years, resistant to multiple medical regimens. Microvascular decompression to relieve pressure on the tenth cranial nerve and medulla oblongata resulted in near total resolution of the singultus. Neurovascular compression should be considered a potentially reversible cause of intractable singultus, a significantly disabling clinical phenomenon.
    Neurosurgery 06/2008; 62(5):E1180-1; discussion E1181. DOI:10.1227/01.neu.0000325888.84785.20 · 3.62 Impact Factor