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Normal Structure, Function, and Histology of the Spleen

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Toxicologic Pathology (Impact Factor: 1.92). 02/2006; 34(5):455-65. DOI: 10.1080/01926230600867743
Source: PubMed

ABSTRACT The spleen is the largest secondary immune organ in the body and is responsible for initiating immune reactions to blood-borne antigens and for filtering the blood of foreign material and old or damaged red blood cells. These functions are carried out by the 2 main compartments of the spleen, the white pulp (including the marginal zone) and the red pulp, which are vastly different in their architecture, vascular organization, and cellular composition. The morphology of these compartments is described and, to a lesser extent, their functions are discussed. The variation between species and effects of aging and genetics on splenic morphology are also discussed.

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    • "outsidethespleenthroughthesplenicveins.Specifically,the lymphocytesafterenteringthemarginalsinuscandirectionally migratetothesurroundingsofthecentralarteryinthearterial terminalbranches(MebiusandKraal,2005;Cesta,2006)toform whitepulp.Onthecontrary,othercellcomponentswillflow alongwiththebloodintotheredpulp.Theredpulpcontains abundantphagocytes,whichwillclearawaytheoldRBCsandthe pathogenicmicroorganism(denHaanetal.,2012). "
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    Frontiers in Microbiology 06/2015; 6:645. DOI:10.3389/fmicb.2015.00645 · 3.94 Impact Factor
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    • "The other is a marginal zone macrophage that is positive for SIGN-R1 and/or MARCO; it plays a major role in filtering and cleaning S. pneumonia. SIGN-R1 binds capsular polysaccharides, such as on S. pneumonia [17] [22] [23], while MARCO binds to S. aureus and Escherichia coli [24]. In addition, marginal zone macrophages and marginal zone B-cells have a direct intercellular interactions via MARCO expressed on marginal zone macrophages with an undetermined ligand on marginal zone B-cells [25]. "
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    • "fenestrae [5], [6]. On the other end, SPIONs with hydrodynamic diameter bigger than the inter-endothelial slits in the spleen (∼200–500 nm) will be retained in the red pulp and eventually cleared by resident macrophage cells [7], [8]. "
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