Article

Urothelial carcinoma with plasmacytoid variants producing both human chorionic gonadotropin and carbohydrate antigen 19-9.

Department of Pathology, Nara Medical University School of Medicine, Nara, Japan.
Urology (impact factor: 2.43). 11/2006; 68(4):891.e7-10. DOI:10.1016/j.urology.2006.05.029 pp.891.e7-10
Source: PubMed

ABSTRACT Plasmacytoid urothelial carcinoma is a rare malignant neoplasm in the urinary bladder. A 46-year-old man presented with gross hematuria and increased serum concentrations of both carbohydrate antigen (CA) 19-9 and beta-human chorionic gonadotropin (beta-hCG). The tumor was composed of conventional urothelial carcinoma and plasmacytoid variant, both positive for epithelial markers. In addition, plasmacytoid tumor cells were positive for an accepted marker of plasma cell origin, CD138. CA19-9 was mainly expressed in conventional urothelial carcinoma cells, and beta-hCG was mainly produced by plasmacytoid tumor cells. This is the first report, to our knowledge, indicating beta-hCG can be produced by plasmacytoid bladder cancer cells lacking trophoblastic features.

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    Article: The many faces of urothelial carcinoma: an update with an emphasis on recently described variants.
    Priya Nigwekar, Mahul B Amin
    [show abstract] [hide abstract]
    ABSTRACT: Urothelial carcinoma is well known for its divergent differentiation. Several "variant" morphologies have been described in the literature in recent years and have additionally been recognized in the recent World Health Organization classification of urothelial neoplasms. The importance of recognizing these variant histologies lies in the potential diagnostic, prognostic, or therapeutic implications that accompany these diagnoses. The range of variant morphology seen in the urinary bladder may also be seen in urothelial tumors of the renal pelvis. Herein we review select variants of urothelial carcinoma focusing on the relatively recently recognized variants, outlining the diagnostic features, common differential diagnostic dilemmas, and clinical relevance. This review also includes a discussion on variants on which there is recent information available.
    Advances in anatomic pathology 08/2008; 15(4):218-33. · 3.22 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

46-year-old man
 
accepted marker
 
beta-hCG
 
beta-human chorionic gonadotropin
 
conventional urothelial carcinoma
 
conventional urothelial carcinoma cells
 
plasma cell origin
 
plasmacytoid bladder cancer cells
 
plasmacytoid tumor cells
 
Plasmacytoid urothelial carcinoma
 
plasmacytoid variant
 
rare malignant neoplasm
 
serum concentrations
 
trophoblastic features
 
tumor
 

Keiji Shimada