UniCAP and multiple-antigen simultaneous test (MAST) are among the widely used specific allergen tests. The Phadiatop and Fx5 are the multi-allergen UniCAP screening tests for inhalant allergens and common food allergens, respectively. We compared the differences between Phadiatop-Fx5 and MAST as screening allergen tests to clarify the optimal tests for different groups of allergic patients. Serum samples of 224 consecutive allergic patients were tested with Phadiatop, Fx5 and MAST. Results of these allergen tests were compared and analyzed in subgroups categorized by age, serum IgE levels and the clinical departments where the patients were treated. We found that among the 224 patients, 155 patients (69.2%) tested positive with Phadiatop while 137 (61.1%) tested positive with MAST for inhalant allergens. Twenty patients were Phadiatop(+)/MAST(-), while only 2 were Phadiatop(-)/MAST(+). There were 57 patients (25.4%) who tested positive with Fx5, while 32 (14.3%) tested positive with MAST for food allergens. Thirty-eight patients were Fx5(+)/MAST(-), while 13 were Fx5(-)/MAST(+). The disagreement between these two tests was more apparent in food allergen tests than in inhalant allergen tests. Most cases of disagreement occurred in younger age groups and in the patient group with IgE > 500 IU/ml. These results suggested that UniCAP allergen screening tests might be more effective in certain patient groups as screening tests.
[Show abstract][Hide abstract] ABSTRACT: We assessed the therapeutic effect of acupuncture in patients with perennial allergic rhinitis. Acupuncture therapy corrects the equilibrium deviation using the bidirectional regulative actions in treating syndromes by inserting needles into acupoints.
We studied the clinical outcomes and gene expression profiles of Phadiatop (Ph)-positive (+) and -negative (-) allergic rhinitis patients who were treated with acupuncture.
Twenty-one (21) patients with allergic rhinitis [13 Ph(+), 8 Ph(-)] received 8 courses of acupuncture treatment over 4 weeks. Blood samples of the patients were collected during the course of acupuncture for global analysis of gene expression profiles by Affymetrix human U133A chips. Patients completed the rhinoconjunctivitis quality of life questionnaire (RQLQ) before and after the therapy to objectively measure the therapeutic effect of acupuncture. The gene expression profile in patients with Ph(+) and Ph(-) allergic rhinitis treated before and after acupuncture was analyzed by unsupervised and supervised clustering methods.
The results of the RQLQ and the gene expression profiles were different between the Ph(+) and Ph(-) groups after receiving treatment with acupuncture. Activity, practical problems, and nasal symptoms showed significant improvement in the Ph(+) group versus the Ph(-) group. In addition, genes involved in active immune response, differential of Treg and cell apoptosis, were different in the Ph(+) and Ph(-) groups after acupuncture treatment.
Differential gene expression profiles of patients with Ph(+) and Ph(-) allergic rhinitis indicate the distinct physiologic responses after receiving acupuncture treatment in these two groups. Our results suggest that personalized medical treatment should be essential for acupuncture treatment in patients with allergic rhinitis.
Journal of alternative and complementary medicine (New York, N.Y.) 01/2010; 16(1):59-68. DOI:10.1089/acm.2009.0024 · 1.59 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Allergic rhinitis (AR) is the most common chronic allergic disease in school-age children. An increased prevalence of attention deficit hyperactivity disorder (ADHD) in AR patients has been reported; however, inattention and hyperactivity in AR children have not been investigated using objective and scientific measurements.
We used AR symptom score, ADHD symptom scale, and computerized continuous performance test (CPT) to study the attention and impulsivity in AR children, age-matched controls, and ADHD children (aged 6-15 years). Univariate and multivariate linear regression analyses were applied to identify risk factors for impulsivity and inattention in AR children.
Twenty-nine controls, 10 ADHD, and 105 AR children were enrolled. There were no differences in age and gender among the three groups. The scores of Hyperactivity/Impulsivity subscales of ADHD symptoms from both parents and teachers were significantly higher in the AR children. The CPT in AR children revealed higher commission errors, shorter reaction times, and more perseveration. Risk factors for inattention and impulsivity in AR children included younger age, male gender, higher AR symptom scores, persistent AR, moderate/severe AR, multiple atopic diseases, family history of atopy, and possible comorbidity with ADHD.
Care for AR children should not only involve treating their allergy, but also monitoring the possible comorbidities of impulsivity and inattention. In children with impulsivity, AR should be considered in addition to ADHD.
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