Article

The cytochromes P450 (CYP) response to allergic inflammation of the lung.

Department of Pharmacology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Archives of Biochemistry and Biophysics (impact factor: 2.93). 01/2007; 456(1):30-8. DOI:10.1016/j.abb.2006.09.029 pp.30-8
Source: PubMed

ABSTRACT The expression of the mouse Cyp family and key inflammatory mediators were examined in a model of ovalbumin (OVA)-induced allergic airway disease. The expression of IL-4, IL-13 and Ccl11 increased during the acute phase of allergic inflammation and decreased with its resolution. Interestingly, the expression of Ccl20 was increased during the resolution phase. The response of the Cyp gene family to the development of allergic inflammation was differential and correlated with the evolution of the inflammatory response. During the acute inflammatory phase the mRNA levels of Cyp2e1, Cyp2f2, Cyp2j6, Cyp4b1, Cyp8a1 and Cypor were decreased while the mRNA levels of Cyp4f18, Cyp5a1 and Cyp7b1 were elevated. With resolution of the inflammation the expression patterns returned to normal. These changes suggest that the Cyp family may play a role in the allergic inflammation by modulating the metabolism of xenobiotics and endogenous compounds such as LTB4, TXA1, PGI2 and native anti-glucocorticoids.

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Keywords

acute inflammatory phase
 
acute phase
 
allergic inflammation
 
Cyp family
 
Cyp gene family
 
Cypor
 
expression patterns
 
inflammatory response
 
Interestingly
 
key inflammatory mediators
 
LTB4
 
metabolism
 
modulating
 
mouse Cyp family
 
mRNA levels
 
native anti-glucocorticoids
 
normal
 
OVA)-induced allergic airway disease
 
ovalbumin
 
resolution phase