Article

Cerebrovascular disease basis of depression: Post-stroke depression and vascular depression

Department of Psychiatry, The Johns Hopkins Hospital, Baltimore, USA.
International Review of Psychiatry (Impact Factor: 1.8). 11/2006; 18(5):433-41. DOI: 10.1080/09540260600935447
Source: PubMed

ABSTRACT The close association between cerebrovascular disease and depression has been known for more than a century, yet much of the progress in understanding the cerebrovascular basis of depression in late life has been spurred by development of two concepts: 'post-stroke depression' and 'vascular depression'. The purpose of this review is to examine the epidemiology, diagnostic features, course, pathophysiology and prognosis of post-stroke depression and vascular depression, to highlight their common features, and to contrast the distinct aspects of these two subtypes of geriatric depression.

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    • "Vascular depression was originally hypothesized to be chronic and persisting. Compared to vascular depression, the course of PSD seems even more complex and dependent on timing of onset [2]. The role of vascular risk factors in the etiology of PSD and vascular depression is less obvious than it appears. "
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    • "We excluded 177 men and 115 women who reported that a doctor had told them they had at least one of the following diseases: CVD, previous stroke, or cancer, or who were taking certain medications with a potential effect on the affective states including antidepressants, sedatives, and antipsychotic medications. The decision to exclude these participants was based on previous findings reporting an affect of these diseases and medications on depression [e.g., Newberg et al., 2006] Additionally, 112 men and 84 women were excluded from the study due to missing data for one of the study parameters. Thus, the final sample consisted of 3,880 apparently healthy employees (2,355 men and 1,525 women). "
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