A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient.

INSERM U707, Epidémiologie, Systèmes d'informations, Modélisation, Paris, F-75012 France.
AIDS (Impact Factor: 6.56). 12/2006; 20(17):2229-31. DOI: 10.1097/01.aids.0000252061.35422.84
Source: PubMed

ABSTRACT A molecular virology analysis performed in an HIV-hepatitis B virus (HBV) co-infected patient showed the emergence of an unusual HBV polymerase gene mutation (rt A181T) under adefovir therapy, conferring resistance to adefovir but not to tenofovir, as proved by in-vitro phenotypic analysis. This observation suggests that careful monitoring of co-infected patients is required to diagnose HBV resistance to nucleos(t)ide analogues, and that tenofovir may be active at least against some of the adefovir-resistant strains.

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