Specific associations of insulin resistance with impaired health-related quality of life in the Hertfordshire Cohort Study

MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
Quality of Life Research (Impact Factor: 2.49). 05/2007; 16(3):429-36. DOI: 10.1007/s11136-006-9129-5
Source: PubMed


Insulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits. This study assessed associations of insulin resistance with health-related quality of life (HRQoL) in different domains of physical and mental health in a large elderly population study. Cross-sectional data of 1212 participants from the Hertfordshire Cohort Study were analysed. Insulin resistance was assessed by the homeostatic model assessment (HOMA-IR), and HRQoL was measured using the SF-36 health survey. Poor HRQoL was defined by a score lower than the sex-specific 10th percentile of each scale, and logistic regressions yielded odds ratios in relation to the HOMA-IR scores. Subsequent analyses adjusted for the influence of age, smoking, alcohol consumption, social class, BMI, coronary heart disease and depression. Results showed an increase in poor HRQoL with an increase in HOMA-IR scores for physical functioning (OR = 2.29; CI: 1.67-3.13), vitality (OR = 1.45; CI: 1.05-2.00), and general health (OR = 1.62; CI: 1.19-2.21). In men, but not in women, associations with physical functioning were independent of confounding variables. The results indicate that insulin resistance is associated with poor HRQoL in domains of physical health, but not in domains of mental health.

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    • "This matched the concept of TCM theory that patients with QDS are usually obese. Previous studies showed impaired biochemical data and hormone peptide level, such as insulin resistance, impaired adiponectin or leptin level and higher triglyceride level, not only adversely affected the health of the T2DM patients, but also badly affected their QOL.[22232425] We obtained similar results. "
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    ABSTRACT: The aim of this study is to explore the correlation of laboratory data, hormone peptides, and quality of life with different traditional Chinese medicine (TCM) syndrome groups in type 2 diabetes patients. Of 513 registered patients, 179 subjects aged between 20 and 65 years and having type 2 diabetes mellitus (T2DM) for more than 1 year were enrolled in the study. All the participants were asked to fill out a questionnaire on diabetic TCM syndrome groups, which was designed by professional TCM doctors, and two questionnaires on the quality of life (QOL), WHOQOL-BREF Taiwan version and Medical Outcomes Study (MOS) Short Form-12 (SF-12). The biochemical characteristics and hormone peptide levels were collected at the same time. The patients in any one of the six TCM syndrome groups had the trend to have worse QOL. Especially, patients with qi deficiency had worse life quality on every aspect compared to those without qi deficiency and were fatter than others. We also found that the subjects who had qi deficiency, qi stagnation, and yin deficiency at the same time had worsened condition. We consider that patients with qi deficiency may also be at a higher risk of developing other complications. They need more advanced health care than others. This self-reported questionnaire will be a reference for health care workers screening those T2DM patients who have a higher possibility of developing other complications. Especially in remote areas, where there is a lack of medical resources, an easy-to-use tool such as the one in the present study for detecting and evaluating disease conditions is needed.
    Journal of Traditional and Complementary Medicine 04/2013; 3(2):126-33. DOI:10.4103/2225-4110.110409
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    • "Previous investigations have demonstrated that individuals with T2DM had worse quality of life, compared with adults without diabetes or with the general population [14–18]. The present study expanded the evidence among individuals with T2DM to those who regularly exercised or tried to lose weight. "
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    ABSTRACT: Objective. To examine the association between exercising regularly and trying to lose weight, and quality of life among individuals with and without type 2 diabetes mellitus (T2DM). Methods. Respondents to the US SHIELD baseline survey reported whether they had tried to lose weight during the previous 12 months and whether they exercised regularly for >6 months. Respondents completed the SF-12 quality-of-life survey one year later. Differences between T2DM respondents (n = 2419) and respondents with no diabetes (n = 6750) were tested using t-tests and linear regression models adjusting for demographics, body mass index (BMI), and diabetes status. Results. After adjustment, exercising regularly was significantly associated with higher subsequent physical and mental component scores (P < .001). After adjustment, trying to lose weight was not associated with higher physical component scores (P = .87), but was associated with higher mental component scores (P = .01). Conclusion. Respondents who reported exercising regularly had significantly better physical and mental quality of life, compared with respondents who did not exercise regularly. Despite exercising regularly, respondents with T2DM had significantly worse quality of life, compared with respondents without diabetes who exercised regularly.
    Journal of obesity 01/2011; 2011(3). DOI:10.1155/2011/172073
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    • "The SF-36 has been shown to have very good psychometric properties, with high internal consistency and testretest reliability values from studies of populations with a range of ages and health conditions in the U.S. [18] and [19] and worldwide [20], [21], [22] and [23]. But, only a few studies have investigated the properties of the SF-36 with Asian samples, primarily Chinese residing in mainland China. "
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    ABSTRACT: This study investigated the psychometric properties of the 36-item Short-Form Health Survey (SF-36) (China version) in older Chinese with diabetes living in Beijing, China. The SF-36 was administered to community-based sample of 182 older adults with diabetes living in Beijing. Data collection was conducted in face-to-face interviews. Reliability and validity were assessed using internal consistency, convergent and discriminant analyses. Exploratory principal components analyses (PCA) were conducted to compare the sample's response patterns with the hypothesized scale constructs. Item level validation of the scale supported the assumptions of the hypothesized structure. Internal consistency reliability (Cronbach's alpha >.70) of the subscales were acceptable except for the General Health subscale (.67). PCA confirmed general support of the two hypothesized dimensional factors and eight concepts (factors). The physical component summary (PCS) and the mental component summary (MCS) explained 62.26% of the variance and the eight factors components explained 67.39% of the variance. Known-group comparisons of scale scores indicated significantly higher levels of functionality for respondents with no blood pressure, heart, or depressive symptomatology problems. The Chinese version of the SF-36 showed good reliability and validity and was culturally equivalent. The scale is appropriate for use with older Chinese adults with diabetes.
    Diabetes research and clinical practice 04/2010; 88(3):273-81. DOI:10.1016/j.diabres.2010.03.005 · 2.54 Impact Factor
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