Mycoplasma qenitalium: Prevalence and behavioural risk factors in the general population

Research Unit for General Practice, Vennelyst Boulevard 6, DK-8000 Aarhus C, Denmark.
Sexually Transmitted Infections (Impact Factor: 3.08). 07/2007; 83(3):237-41. DOI: 10.1136/sti.2006.022970
Source: PubMed

ABSTRACT Mycoplasma genitalium has been shown to cause urethritis in men and cervicitis in women and may also be a causative agent in female infertility.
To estimate the prevalence of urogenital M genitalium infection and identify sexual behavioural risk factors in the general population.
Participating individuals were 731 men and 921 women aged 21-23 years and not seeking the healthcare system because of symptoms. They answered questionnaires on sexual behaviour and provided samples for M genitalium testing.
In women aged 21-23 years, the prevalence of infection was 2.3% (21/921) and in men of the same age it was 1.1% (8/731). For both sexes, an increasing number of partners was associated with a greater chance of being infected. Among women a shorter duration of a steady relationship and having a partner with symptoms was associated with being infected, and for men younger age at first intercourse was associated with M genitalium infection.
We conclude that the prevalence of infection in the general population is too low for population-based screening. However, the development of test algorithms based on behavioural risk factors is a promising alternative.

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Available from: Berit Andersen, Jul 29, 2015
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    • "Many studies confirm low percentage of M. genitalium in healthy women without symptoms: 4.5% of positive cases were described by English authors [24]. In Denmark, among 731 men and 921 women aged 21–23 without any symptoms in the urogenital tract, M. genitalium DNA was demonstrated in 2.3% women and in 1.1% men [25]. M. genitalium is clearly defined as an etiologic agent of STI. "
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    ABSTRACT: Bacterial infections, especially endogenous, are the frequent complications among hemodialyzed and renal transplant patients. In this study we assumed the prevalence of urogenital mycoplasmas and HPV among hemodialysed women. We examined 32 hemodialysed women aged 20-48 (mean 35.6 ± 8.23) and 100 healthy controls of the same ages. Two swabs were collected for detection of mycoplasmas and HPV. Culture of Ureaplasma spp. and M. hominis was performed using Mycoplasma IST2 (bioMérieux, France), Identificaton of U. parvum and U. urealyticum was performed by Kong. Primers described by Jensen were used for M. genitalium. For detection of high-risk HPV types Amplicor HPV (Roche Molecular System, CA) was used. Prevalence of urogenital mycoplasmas in the hemodialysed women (53.1%) was significantly higher (P = 0.0059), compared with controls (25%). In both groups, U. parvum was the most frequently isolated. Cooccurrence of urogenital mycoplasmas was shown in 75% of the HPV-positive hemodialysed women and in 30.4% of HPV-positive controls (P = 0.0461). Cooccurrence of urogenital mycoplasmas with HPV was significantly higher in hemodialysed women. The need to take into account these microorganisms in routine diagnostic, especially for hemodialysed patients, was demonstrated. Further studies to demonstrate the role of this cooccurrence in etiopathogenesis of infection in hemodialysed patients are required.
    The Scientific World Journal 12/2013; 2013:659204. DOI:10.1155/2013/659204 · 1.73 Impact Factor
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    • "In 2009, for this subsequent study, previously collected urine samples stored at −70 • C were tested for M. genitalium and C. trachomatis. M. genitalium PCR testing has been conducted in other studies stored frozen specimens for up to eight years [19] [27] [28]. Of the 285 samples sent for analysis, 216 samples (82 cases and 134 controls) were sufficient for analysis. "
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    ABSTRACT: As the consequences of Mycoplasma genitalium in pregnant women are unknown, we examined the relationship between prenatal M. genitalium infection and SAB. The presence of M. genitalium was determined by PCR in urine from 82 women who subsequently experienced a SAB and 134 women who maintained their pregnancies past 22 weeks gestation. The relationships between M. genitalium and subsequent SAB, demographic, current pregnancy, and reproductive health history characteristics were evaluated. Compared to women without M. genitalium, women with M. genitalium were more likely to report nulliparity (41.7% versus 17.4%, P = .04), history of pelvic inflammatory disease (27.3% versus 8.8%, P = .08), prior C. trachomatis infection (63.6% versus 36.9%, P = .11,) and problems getting pregnant (18.2% versus 4.4%, P = .10). M. genitalium was not associated with SAB (AOR 0.9, 95% CI 0.2-3.8). Pregnant women who test positive for M. genitalium do not have an increased risk of SAB but report a history of reproductive morbidities.
    Infectious Diseases in Obstetrics and Gynecology 03/2010; 2010:984760. DOI:10.1155/2010/984760
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    ABSTRACT: Five mycoplasma species, Mycoplasma pneumoniae, M. hominis, M. genitalium, Ureaplasma urealyticum and U. parvum, here designed as Ureaplasma spp., are responsible for human infections.M. pneumoniae is the only mycoplasma clearly pathogen for the respiratory tract. Implicated most often in trachéobronchtes, it is the second agent responsible for bacterial community-acquired pneumonia and is probably involved in asthma exacerbation. M. pneumoniae infections occur endemically with epidemic peaks every 4 – 7 years, mostly in children above 5 years. The biological diagnosis of these infections is made only in severe infections, mainly by serology because of the fastidious character of the microorganism. However, M. pneumoniae can be easily detected by molecular amplification techniques.The other mycoplasma species are mainly responsible for infections of the urogenital tract. M. genitalium is the second agent of non gonococcal urethritis after Chlamydia trachomatis. Ureaplasma spp. is also involved in chronic urethritis but can be present, like M. hominis but more often, as a commensal of the lower genital tract. All species are responsible for infections of the genital tract of women. Ureaplasma spp. and M. hominis, other species rarely, are involved in infections in immunocompromised patients. The only method adapted to the detection of M. genitalium, a very fastidious mycoplasma, is amplification technique. The other species can relatively easily be detected by culture but the main problem is to interpret the results because of their possible presence as commensals.
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