Atypical congenital mesoblastic nephroma presenting in the perinatal period
Department of Paediatric surgery, The Children's Hospital at Westmead, Corner Hawkesbury Road and Hainsworth Street, Locked Bag 4001, Westmead, Sydney, 2145 NSW, Australia.Pediatric Surgery International (Impact Factor: 1). 04/2007; 23(3):205-9. DOI: 10.1007/s00383-006-1831-4
Congenital mesoblastic nephroma (CMN) is a rare tumour of infancy having an overall good prognosis. The less common, atypical CMNs have cellular elements in them and tend to have an unpredictable course. Occurrence in the perinatal period may further change the outcome. By reporting three patients presenting in the perinatal period with atypical CMN, an attempt is made in this paper to characterize the clinical behaviour of these variant tumours. Though one of our patients had an uneventful course, the other two had several complications including polyhydramnios, prematurity, hypertension, haemodynamic instability and tumour spillage. The course was complicated by recurrence in the latter two and refractoriness to chemotherapy and death in one. That the atypical subset of CMNs occurring in the perinatal period can have a stormy course is well illustrated by this report. Possible prognostic factors are evaluated and the sparse reports of similar cases in the literature are reviewed and compared.
Article: Fetal oncology[Show abstract] [Hide abstract]
ABSTRACT: The author presents a review of benign and malignant tumors that may affect the fetus. Virtually all tumors that occur in children and adults may also develop in the fetus, and can be found in the neonate. For their early diagnosis ultrasonography and magnetic resonance imaging are of critical importance. These techniques represent the cutting edge of contemporary diagnostic technology. Regretfully, the progress in perinatal diagnostic methodology has not been matched, as yet, by comparable therapeutic options. These are still in their experimental stages. Only a few centers perform surgical interventions. Options vary about the risk-benefit ratios of the respective operative procedures.Orvosi Hetilap 01/2008; 148(50):2377-84. DOI:10.1556/OH.2007.28011
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ABSTRACT: This is a review of renal tumors diagnosed between 1960 and 2007 in 47 fetuses and 163 infants less than 2 months old. There were 139 congenital mesoblastic nephromas, 41 Wilms' tumors, 23 rhabdoid tumors of the kidney, and 7 clear cell sarcomas of the kidney. The initial clinical manifestations, staging, management, and outcome of these patents are summarized in the tables and text.Journal of Pediatric Surgery 10/2008; 43(9):1587-95. DOI:10.1016/j.jpedsurg.2008.03.052 · 1.39 Impact Factor
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ABSTRACT: Congenital mesoblastic nephroma is a rare renal tumor of early infancy with a favorable outcome after complete surgical removal. It consists of a heterogeneous group of spindle cell tumors. Early and accurate prenatal diagnosis of the renal tumor may improve the outcome of affected pregnancies by implementing the best strategy for prenatal management and delivery. But detection of congenital mesoblastic nephroma in a fetus is rare. To the authors' knowledge, there are fewer than 30 reports of a prenatal diagnosis of a mesoblastic nephroma in the literature. This case describes the prenatal sonographic diagnosis of cellular congenital mesoblastic nephroma.Journal of Diagnostic Medical Sonography 03/2009; 25(2):112-115. DOI:10.1177/8756479309333107
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