Isolation and characterisation of impurities in adapalene

Dipartimento di Chimica, Materiali ed Ingegneria Chimica del Politecnico, Istituto CNR per la Chimica del Riconoscimento Molecolare, Via Mancinelli 7, I-20131 Milano, Italy.
Journal of Pharmaceutical and Biomedical Analysis (Impact Factor: 2.98). 03/2007; 43(3):1161-3. DOI: 10.1016/j.jpba.2006.09.035
Source: PubMed


Three impurities of structure 2-4 were isolated and characterised during the optimisation of a synthetic procedure to adapalene. Impurity 1 was a by-product of the Friedel-Crafts reaction of adamantanol with 4-bromoanisole. Impurities 3 and 4 were due to side reactions of the final Negishi coupling.

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