Intact attentional control of working memory encoding in schizophrenia

Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Journal of Abnormal Psychology (Impact Factor: 4.86). 12/2006; 115(4):658-73. DOI: 10.1037/0021-843X.115.4.658
Source: PubMed

ABSTRACT This study reports evidence that individuals with schizophrenia (SC) demonstrate intact attentional selection for visual working memory (WM) storage. A group of 62 participants with SC and 55 control participants without SC were studied in a series of 5 experiments that examined the ability to use top-down and bottom-up cues to guide WM encoding, as well as the ability to spontaneously select a subset of representations for storage. Participants with SC exhibited a consistent and robust ability to use selective attention in the control of WM in all 5 experiments, demonstrating a remarkable island of preserved functioning given the broad spectrum of impairments of attention and WM that have been widely reported in those with SC. These findings indicate that attention is not globally impaired in SC and make it possible to delineate more precisely the nature of the specific impairment of attention in this disorder.

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Available from: Rebecca L Fuller, Aug 01, 2015
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    • "We found no impairment of attention in D2R-OE mice. Although impairments in attention (broadly defined) have been widely reported in schizophrenia (Heinrichs & Zakzanis, 1998; Demeter, Guthrie, Taylor, Sarter, & Lustig, 2013; Nuechterlein et al., 2004), detailed analysis of the specific nature of attentional deficits in schizophrenia shows unimpaired selection of highly salient inputs for attentional processing (Gold et al., 2006; Luck & Gold, 2008), as in our sustained-attention task. Instead, patients with schizophrenia are impaired in the executive control of attention , such as guided searching and resistance to distraction (Luck & Gold, 2008). "
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    ABSTRACT: Interactions between motivation and cognition are implicated in producing functional impairments and poor quality of life in psychiatric patients. This interaction, however, is not well understood at either the behavioral or neural level. We developed a procedure for mice in which a cognitive measure, sustained attention, is modulated by a motivationally relevant signal that predicts reward probability on a trial-by-trial basis. Using this paradigm, we tested the interaction between motivation and cognition in mice that model the increased striatal D2 receptor activity observed in schizophrenia patients (D2R-OE mice). In control mice, attention was modulated by signaled-reward probability. In D2R-OE mice, however, attention was not modulated by reward-related cues. This impairment was not due to any global deficits in attention or maintenance of the trial-specific information in working memory. Turning off the transgene in D2R-OE mice rescued the motivational modulation of attention. These results indicate that deficits in motivation impair the ability to use reward-related cues to recruit attention and that improving motivation improves functional cognitive performance. These results further suggest that addressing motivational impairments in patients is critical to achieving substantive cognitive and functional gains. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
    Behavioral Neuroscience 04/2015; 129(3). DOI:10.1037/bne0000051 · 3.25 Impact Factor
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    • "Similarly, Smith et al. (2011) found that PSZ were able to use color cues to guide target words into WM storage and exclude non-target words—again, despite overall reductions in capacity. These recent studies are consistent with earlier work from Gold et al. (2006) demonstrating that PSZ are able to select task-relevant items for WM storage while inhibiting the encoding of task-irrelevant items. One exception may be a failure to filter out extremely salient distractors (especially those that strongly activate the magnocellular pathway) during the encoding of low-salience target items (Hahn et al., 2010; Leonard et al., 2014). "
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    ABSTRACT: Although working memory impairment has been well-documented among people with schizophrenia (PSZ), the underlying mechanism of this impairment remains unknown. The present study was conducted in a large sample of PSZ and healthy control subjects (HCS) to test the hypothesis that one putative mechanism – vulnerability to distraction from task-irrelevant stimuli – (1) can account for working memory impairment among PSZ, and (2) is associated with other neurocognitive and clinical variables that are highly predictive of functional outcome in schizophrenia. Participants (127 PSZ and 124 HCS) completed a visual change detection task in which a distractor stimulus (mask) was presented on half of the trials during the delay period between sample and test array. PSZ lost proportionately more information from working memory than did HCS, but this effect was small (Cohen’s d = 0.36–0.38), and large differences between groups in working memory capacity remained when differences in distractibility were factored out. Furthermore, vulnerability to distraction was not strongly associated with any clinical or cognitive variables of interest. These results suggest that, although PSZ may be somewhat more susceptible to distraction than HCS, this impairment is unlikely to be a significant factor accounting for the robust capacity deficits observed in this population.
    09/2014; 1(3). DOI:10.1016/j.scog.2014.09.001
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    • "The importance of our findings for further theorizing about relationships between attention and WMC therefore lies in the performance of the low-capacity individuals. While it is acknowledged that high-capacity individuals may control their performance flexibly, individuals with low WMC are expected to be far less capable of this, despite evidence suggesting that individuals from populations with low WMC (e.g., young children or schizophrenic patients; Cowan et al., 2010; Gold et al., 2006) can ignore distracting information as well as higher-capacity populations, as well as mounting evidence that WMC does not universally correlate with efficient selective attention in healthy young adults (e.g., Beaman, 2004; Poole & Kane, 2009). In our sample, WMC scores were positively related to the tendency to attend less relevant information in Experiment 1, where individuals were not explicitly instructed to attend to one type of information over another. "
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    ABSTRACT: Selective attention and working memory capacity (WMC) are related constructs, but debate about the manner in which they are related remains active. One elegant explanation of variance in WMC is that the efficiency of filtering irrelevant information is the crucial determining factor, rather than differences in capacity per se. We examined this hypothesis by relating WMC (as measured by complex span tasks) to accuracy and eye movements during visual change detection tasks with different degrees of attentional filtering and allocation requirements. Our results did not indicate strong filtering differences between high- and low-WMC groups, and where differences were observed, they were counter to those predicted by the strongest attentional filtering hypothesis. Bayes factors indicated evidence favoring positive or null relationships between WMC and correct responses to unemphasized information, as well as between WMC and the time spent looking at unemphasized information. These findings are consistent with the hypothesis that individual differences in storage capacity, not only filtering efficiency, underlie individual differences in working memory.
    Attention Perception & Psychophysics 01/2014; 76(7). DOI:10.3758/s13414-013-0610-2 · 2.15 Impact Factor
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