Article

Animal models of pheochromocytoma including NIH initial experience.

Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, NIH, Building 10, CRC, Room 1E-3141, 10 Center Drive MSC-1109, Bethesda, MD 20892-1109, USA.
Annals of the New York Academy of Sciences (impact factor: 3.15). 09/2006; 1073:300-5. DOI:10.1196/annals.1353.034 pp.300-5
Source: PubMed

ABSTRACT Mouse models have been used to study the mechanisms underlying the carcinogenesis of a wide variety of human cancer. A considerable number of mouse and rat models, used for the study of elementary tumorgenic mechanisms, were found to develop pheochromocytomas. Some of these models resemble hereditary syndrome-related pheochromocytoma in humans and some may serve as a new starting point for human pheochromocytoma research. Recently, we generated a model of catecholamine-producing metastatic pheochromocytoma in athymic nude mice using tail-vein injection of mouse pheochromocytoma cells (MPCs). This and alternative animal models of metastatic pheochromocytoma are promising avenues in preclinical studies to evaluate new therapeutic approaches for malignant pheochromocytoma.

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Keywords

alternative animal models
 
athymic nude mice
 
catecholamine-producing metastatic pheochromocytoma
 
hereditary syndrome-related pheochromocytoma
 
human pheochromocytoma research
 
metastatic pheochromocytoma
 
models
 
Mouse models
 
mouse pheochromocytoma cells
 
MPCs
 
new therapeutic approaches
 
pheochromocytomas
 
preclinical studies
 
rat models
 
wide variety
 

Shoichiro Ohta