Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis

Hôpital Bicêtre (Hôpitaux Universitaires Paris-Sud), Lutetia Parisorum, Île-de-France, France
Journal of Inherited Metabolic Disease (Impact Factor: 4.14). 01/2007; 29(6):763. DOI: 10.1007/s10545-006-0408-7
Source: PubMed

ABSTRACT Hyper-IgD and periodic fever syndrome (HIDS) is a hereditary autoinflammatory syndrome, characterized by recurrent inflammatory attacks. Treatment of HIDS is difficult. Recently, the IL-1ra analogue anakinra was reported to be successful in aborting the IgD inflammatory attacks in a vaccination model. We report a clinical case of spectacular reduction of febrile attacks in a severe HIDS patient.

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