Article

Management of comorbid bipolar disorder and substance abuse.

Psychoneuroendocrine Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.
The Journal of Clinical Psychiatry (impact factor: 5.8). 09/2006; 67(8):e05. pp.e05
Source: PubMed

ABSTRACT Rates of alcohol and other substance abuse or dependence disorders are substantially higher in persons with bipolar disorders than in the general population, reaching approximately 61% in patients with bipolar I disorder. As a result, clinicians must be prepared to treat substance use disorders and bipolar disorder simultaneously. This presentation reviews data from the 4 published randomized, controlled trials of pharmacotherapy (lithium, carbamazepine, valproate, and quetiapine) in this population. Also reviewed are data from promising open-label, uncontrolled trials. While the results of published research have been generally positive and support the efficacy and tolerability of several agents from different classes in patients with a dual diagnosis of bipolar disorder and substance abuse or dependence, more randomized, controlled research is needed.

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Keywords

agents
 
bipolar
 
bipolar disorder
 
bipolar disorders
 
carbamazepine
 
dependence disorders
 
different classes
 
general population
 
patients
 
pharmacotherapy
 
presentation reviews data
 
promising open-label
 
substance abuse
 
substance use disorders
 
tolerability
 

E Sherwood Brown