Article

Pheromonal communication in vertebrates.

Department of Physiology, University of Bristol, Medical School Building, University Walk, Bristol BS8 1TD, UK.
Nature (Impact Factor: 38.6). 12/2006; 444(7117):308-15. DOI: 10.1038/nature05404
Source: PubMed

ABSTRACT Recent insights have revolutionized our understanding of the importance of chemical signals in influencing vertebrate behaviour. Previously unknown families of pheromonal signals have been identified that are expanding the traditional definition of a pheromone. Although previously regarded as functioning independently, the main olfactory and vomeronasal systems have been found to have considerable overlap in terms of the chemosignals they detect and the effects that they mediate. Studies using gene-targeted mice have revealed an unexpected diversity of chemosensory systems and their underlying cellular and molecular mechanisms. Future developments could show how the functions of the different chemosensory systems are integrated to regulate innate and learned behavioural and physiological responses to pheromones.

1 Bookmark
 · 
112 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Mate preference behavior is an essential first step in sexual selection and is a critical determinant in evolutionary biology. Previously an environmental compound (the fungicide vinclozolin) was found to promote the epigenetic transgenerational inheritance of an altered sperm epigenome and modified mate preference characteristics for three generations after exposure of a gestating female.
    BMC genomics. 05/2014; 15(1):377.
  • [Show abstract] [Hide abstract]
    ABSTRACT: In addition to the TSH-cyclic AMP signalling pathway, calcium signalling is of crucial importance in thyroid cells. Although the importance of calcium signalling has been thoroughly investigated for several decades, the nature of the calcium channels involved in signalling is unknown. In a recent series of investigations using the well-studied rat thyroid FRTL-5 cell line, we showed that these cells exclusively express the transient receptor potential canonical 2 (TRPC2) channel. Our results suggested that the TRPC2 channel is of significant importance in regulating thyroid cell function. These investigations were the first to show that thyroid cells express a member of the TRPC family of ion channels. In this review, we will describe the importance of the TRPC2 channel in regulating TSH receptor expression, thyroglobulin maturation, intracellular calcium and iodide homeostasis and that the channel also regulates thyroid cell proliferation.
    Pflügers Archiv - European Journal of Physiology 04/2014; · 4.87 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We analyzed the expression of G protein alpha subunits and the axonal projection into the brain in the olfactory system of the semi-aquatic newt, Cynops pyrrhogaster by immunostaining with antibodies against Gαolf and Gαo, in situ hybridization using probes for Gαolf, Gαo and Gαi2, and neuronal tracing with DiI and DiA. The main olfactory epithelium (OE) consists of two parts, the ventral OE and dorsal OE. In the ventral OE, the Gαolf- and Gαo-expressing neurons are located in the apical and basal zone of the OE, respectively. This zonal expression was similar to that of the OE in the middle cavity of the fully aquatic toad, Xenopus laevis. However, the Gαolf- and Gαo-expressing neurons in the newt ventral OE project their axons towards the main olfactory bulb (MOB) and the accessory olfactory bulb (AOB), respectively, whereas in Xenopus, the axons of both neurons project solely towards the MOB. In the dorsal OE of the newt as in the principal cavity of Xenopus, the majority of the neurons express Gαolf and extend their axons into the MOB. In the vomeronasal organ (VNO), the neurons mostly express Gαo. These neurons and quite a few Gαolf-expressing neurons project their axons towards the AOB. This feature is similar to that in the terrestrial toad, Bufo japonicus and is different from that in Xenopus, of which VNO neurons express solely Gαo, although their axons invariably project towards the AOB. We discuss the findings in the light of diversification and evolution of the vertebrate olfactory system. J. Comp. Neurol., 2014. © 2014 Wiley Periodicals, Inc.
    The Journal of Comparative Neurology 04/2014; · 3.66 Impact Factor

Full-text (2 Sources)

View
23 Downloads
Available from
May 30, 2014