Article

Pharmacologic management of insomnia: past, present, and future.

Sleep Medicine and Research Center, St John's Mercy Medical Center and St Luke's Hospital, Chesterfield, MO 63017, USA.
Psychiatric Clinics of North America (Impact Factor: 2.13). 01/2007; 29(4):871-93; abstract vii-viii. DOI: 10.1016/j.psc.2006.09.006
Source: PubMed

ABSTRACT Views on the etiology and morbidities associated with insomnia are evolving and affect clinicians' approach to the pharmacologic management of insomnia. Currently, benzodiazepine receptor agonists (BzRAs) and a single melatonin receptor agonist are recognized as safe and efficacious hypnotics. Variability in BzRAs, pharmacokinetics, and manipulation of dose provide clinicians with options that meet the needs of most patients. Other drugs (eg, sedating antidepressants) also are used commonly in clinical practice to treat insomnia, but evidence is lacking to support this most cases. Improvement in managing insomnia will result from systematic research with these drugs, with drugs in development, and with novel uses, such as co-therapy.

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