Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2
ABSTRACT Women who carry mutations in either the BRCA1 or BRCA2 genes are at risk for early-onset breast cancer and are recommended to begin screening mammography at age 25 to 30 years. Results of in vitro and animal studies suggest that BRCA1/BRCA2 mutation carriers are hypersensitive to ionizing radiation and possibly to radiation-induced breast cancer. This study was undertaken to investigate the association of low-dose radiation exposure from mammograms with breast cancer status in BRCA mutation carriers. One hundred sixty-two female mutation carriers provided information at time of genetic testing about exposure to mammograms before enrollment. Using unconditional logistic regression, breast cancer status was not associated with number of mammograms received before diagnosis (affected women) or ascertainment [unaffected women; adjusted odds ratio (OR), 0.94; P = not significant]. A larger group of 213 women provided information about lifetime number of mammograms. There was no association between mammogram exposure and risk in the group as a whole (adjusted OR, 1.04; P = not significant), although there was a modest association in BRCA1 carriers (adjusted OR, 1.08; P = 0.03). These findings indicate that screening mammography is unlikely to be associated with a large increase in breast cancer risk in this population.
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ABSTRACT: An ergometric system for measuring the energy expenditure due to muscular activity of small mammals is described. The method is based on measuring the vibrations induced in a platform on which the animal is living. The capability to detect and quantify low energy levels transmitted by shivering is used to conclude that hypothyroid rats must rely mostly on shivering thermogenesis to resist moderate cold exposure
Conference Paper: Grumman's real time automated test system[Show abstract] [Hide abstract]
ABSTRACT: In this system, up to five test articles can be supported concurrently in real time. Data are received via both low- and high-speed telemetry links into a common data acquisition subsystem. The data acquisition subsystem consists of Metraplex and Aydin monitor hardware. Data is then routed into several-purpose telemetry preprocessors where they are tagged, edited and processed. The low-speed telemetry preprocessors are designed to use SEL 3270 computers. The new high-speed telemetry preprocessors use VAX 8600 coupled with Micro VAX II. In the architecture, the analysis and display elements have been combined to form an intelligent workstation environment using commercially available computers and displays. Each workstation can execute several real-time programs and direct data to two 19" high resolution monitors. Function keys, programmable latch keys and other user friendly input devices allow the test engineer to interact with the system and support the test requirementsEuropean Test Conference, 1989., Proceedings of the 1st; 05/1989
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ABSTRACT: The cancer susceptibility genes BRCA1 and BRCA2 appear to be responsible for virtually all hereditary breast ovarian families, and a smaller subset of hereditary site-specific breast cancer families. Fortunately, effective strategies have been developed to reduce the risk for the development of breast and ovarian cancer in women with BRCA1/2 mutations, making genetic testing for these mutations an important part of the management at women with a strong family history of these diseases. Here, we review the current evidence for risk reduction strategies and outline future research directions.Oncogene 10/2006; 25(43):5825-31. DOI:10.1038/sj.onc.1209881 · 8.56 Impact Factor