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    • "In the United States, the prevalence of childhood asthma doubled from approximately 3% in early 1980 to 7.5% in 1995 [40]. Atopic diathesis or atopic disease has become an important public health problem among children [1] [17] [19] [36]. "
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    ABSTRACT: Objective Previous studies have found a temporal concordance in the increased prevalence of atopic diathesis/atopic diseases, attention-deficit hyperactivity disorder (ADHD), and autistic spectrum disorder (ASD) worldwide. But, the temporal association among these 3 distinct diseases is unknown. Method 14,812 atopic subjects diagnosed with any atopic disease (asthma, atopic dermatitis, allergic rhinitis, or allergic conjunctivitis) before the age of 3 (atopic cohort) and 6944 non-atopic subjects with no lifetime atopic disease (non-atopic cohort), born between 1997 and 2000, were enrolled and followed to December 31 2010 to identify the development of ADHD and ASD. Results The presence of any atopic disease in early childhood increased the risk of developing ADHD (hazard ratio [HR]: 1.97) and ASD (HR: 3.40) in later life. Greater numbers of atopic comorbidities (4 comorbidities: ADHD: HR: 2.53; ASD: HR: 4.29) were significantly related to a greater risk of developing ADHD and ASD. Discussion Atopic diathesis in early childhood elevated the risk of developing ADHD and ASD in later life, with the dose-dependent relationship of more atopic comorbidities with a greater likelihood of ADHD and ASD.
    Journal of Psychosomatic Research 10/2014; 77(4). DOI:10.1016/j.jpsychores.2014.06.006 · 2.84 Impact Factor
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    • "Allergic asthma is an inflammatory disease of the airways which occurs with increased prevalence during the last decades especially in the developed world910. However, the molecular mechanism of this disease needs further investigations. "
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    ABSTRACT: In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and IL-13. We also observed increased Th9 cells expressing IL-9 and IL-10 as well as T helper cells expressing IL-6, IL-10 and IL-21 with a defect in IL-17A and IL-17F production. This T helper phenotype was accompanied by increased SOCS3 in the lung of Tyk-2 deficient asthmatic mice. Finally, in vivo treatment with rIL-17A inhibited local CD4(+)CD25(+)Foxp3(+) T regulatory cells as well as Th2 cytokines without affecting IL-9 in the lung. These results suggest a role of Tyk-2 in different subsets of T helper cells mediated by SOCS3 regulation that is relevant for the treatment of asthma, cancer and autoimmune diseases.
    Scientific Reports 08/2014; 4:5865. DOI:10.1038/srep05865 · 5.58 Impact Factor
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    • "In addition to improved hygiene, the nutritional change that has occurred in the Western world over the past few decades and the more recent ''Westernization'' of many countries coincide with the rise in the prevalence of asthma, allergy (Eder et al., 2006), and certain autoimmune diseases. Indeed, the change in dietary foodstuffs and the correlation with disease are particularly evident in epidemiological studies correlating fiber and fat intake. "
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    ABSTRACT: One explanation for the increased incidence of allergies, asthma, and even some autoimmune diseases has been the hygiene hypothesis. However, recent studies also highlight an important role for diet and bacterial metabolites in controlling various immune pathways, including gut and immune homeostasis, regulatory T cell biology, and inflammation. Dietary-related metabolites engage "metabolite-sensing" G-protein-coupled receptors, such as GPR43, GPR41, GPR109A, GPR120, and GPR35. These receptors are expressed on immune cells and some gut epithelial cells and generally mediate a direct anti-inflammatory effect. Insufficient intake of "healthy foodstuffs" adversely affects the production of bacterial metabolites. These metabolites and those derived directly from food drive beneficial downstream effects on immune pathways. We propose that insufficient exposure to dietary and bacterial metabolites might underlie the development of inflammatory disorders in Western countries. This review highlights what is currently known about diet, metabolites, and their associated immune pathways in relation to the development of inflammatory disease.
    Immunity 06/2014; 40(6):833-842. DOI:10.1016/j.immuni.2014.05.014 · 19.75 Impact Factor
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