Central corneal thickness in the European Glaucoma Prevention Study.
ABSTRACT To measure central corneal thickness (CCT) within the participants of the European Glaucoma Prevention Study (EGPS). This study was designed to test if lowering intraocular pressure (IOP) by means of dorzolamide is able to prevent or delay conversion from ocular hypertension to glaucoma.
Randomized, double-masked, controlled, observational clinical trial.
Eight hundred fifty-four of 1077 ocular hypertensive participants within the EGPS were investigated. Four hundred twenty-nine patients were treated with dorzolamide and 425 patients received placebo.
Treatment with dorzolamide or placebo (the vehicle of dorzolamide) in 1 or both eyes.
Central corneal thickness as measured by ultrasound pachymetry (DGH-500 Pachette; DGH Technologies, Exton, PA). The CCT measurements were obtained in the morning before measuring IOP. Five measurements were taken from each eye of each patient within 5 minutes of application of anesthetic eye drops.
Mean CCT was 572.6+/-37.4 microm (range, 458.5-695.6 microm). The CCT was higher in younger patients, male patients, and diabetic patients. Mean CCTs for the 429 patients receiving dorzolamide were 574.2+/-38.48 microm (range, 458.5-695.6 microm) and 571.0+/-36.21 microm (469.7-690.1 microm) for the 425 patients receiving placebo (P = 0.205). Central corneal thickness did not correlate with refraction, baseline IOP, or systemic hypertension.
Central corneal thickness measurements within the EGPS were greater than those reported in other studies of normal eyes without ocular hypertension. Larger CCT measurements correlated with male gender, younger age, and diabetes.
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ABSTRACT: The results of the Ocular Hypertension Treatment Study (OHTS) brought to the forefront the role of central corneal thickness (CCT) as a confounder of applanation tonometry, and established CCT as an independent predictive factor for the development of glaucoma. Ophthalmologists often wonder how to use CCT in daily practice. This article reviews the current CCT literature and provides some basic guidance to clinicians wishing to integrate CCT into their care of glaucoma patients.Canadian Journal of Ophthalmology 09/2007; 42(4):562-6. · 1.47 Impact Factor
Article: The ocular biometric and corneal topographic characteristics of high-anisometropic adults in Taiwan.[show abstract] [hide abstract]
ABSTRACT: To investigate the difference of ocular biometric and corneal topographic characteristics between the two eyes in high anisometropes with difference of 4 D or more in spherical component. Fifty-one young anisometropic men were collected. Detailed ocular examinations, including cycloplegic autorefraction, best-corrected visual acuity, intraocular pressure, A-scan, and Orbscan topography were done and recorded. The comparisons between two eyes were performed and the correlations between different ocular parameters were evaluated. The mean axial length in the more myopic/less hyperopic eye was longer than that in the less myopic/more hyperopic eye [difference 1.8 mm, 95% confidence interval (CI) 1.6-2.0 mm, p < 0.001]. The mean thinnest corneal thickness in the more myopic/less hyperopic eye was an average of 4.0 μm thicker than that in the other eye (95% CI 1.2-6.8 μm, p = 0.007). The mean anterior chamber depth in the more myopic/less hyperopic eye was an average of 0.05 mm (95% CI 0.02-0.07 mm, p < 0.001) more than that in the other eye. The curvature and size of cornea were not significantly different. The anterior chamber depth is deeper, axial length is longer, and thinnest corneal thickness is thicker in the more myopic/less hyperopic eye of high-anisometropic patients. Anisometropic eyes provide the chance to understand the biometric changes of eyeball with different refractive statuses in the same person. Such information is helpful for us to calculate the intraocular lenses power in cataract surgery and to do the surgical planning for corneal refractive surgery in eyes of different refractive power.Journal of the Chinese Medical Association 07/2011; 74(7):310-5. · 0.79 Impact Factor
Article: Correlation between Central Corneal Thickness and Refractive Indices in a Laser Refractive Surgery PopulationIranian Journal of Ophthalmology. 01/2010; 22(4):43-48.