Central corneal thickness in the European Glaucoma Prevention Study.
ABSTRACT To measure central corneal thickness (CCT) within the participants of the European Glaucoma Prevention Study (EGPS). This study was designed to test if lowering intraocular pressure (IOP) by means of dorzolamide is able to prevent or delay conversion from ocular hypertension to glaucoma.
Randomized, double-masked, controlled, observational clinical trial.
Eight hundred fifty-four of 1077 ocular hypertensive participants within the EGPS were investigated. Four hundred twenty-nine patients were treated with dorzolamide and 425 patients received placebo.
Treatment with dorzolamide or placebo (the vehicle of dorzolamide) in 1 or both eyes.
Central corneal thickness as measured by ultrasound pachymetry (DGH-500 Pachette; DGH Technologies, Exton, PA). The CCT measurements were obtained in the morning before measuring IOP. Five measurements were taken from each eye of each patient within 5 minutes of application of anesthetic eye drops.
Mean CCT was 572.6+/-37.4 microm (range, 458.5-695.6 microm). The CCT was higher in younger patients, male patients, and diabetic patients. Mean CCTs for the 429 patients receiving dorzolamide were 574.2+/-38.48 microm (range, 458.5-695.6 microm) and 571.0+/-36.21 microm (469.7-690.1 microm) for the 425 patients receiving placebo (P = 0.205). Central corneal thickness did not correlate with refraction, baseline IOP, or systemic hypertension.
Central corneal thickness measurements within the EGPS were greater than those reported in other studies of normal eyes without ocular hypertension. Larger CCT measurements correlated with male gender, younger age, and diabetes.
- SourceAvailable from: James BrandtCanadian Journal of Ophthalmology-journal Canadien D Ophtalmologie - CAN J OPHTHALMOL-J CAN OPHTAL. 01/2007; 42(4):562-566.
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ABSTRACT: To determine the relationship between central corneal thickness (CCT) and myopia among Saudi adults. In a prospective study, the CCT of 982 myopic eyes and 158 emmetropic eyes as a control group was measured using ultrasound pachymetry at the Eye Consultants Center, Riyadh, Saudi Arabia. The mean myopic spherical equivalent (SE) was -3.7 +/- 2.12 D, range -0.25 to -15.0 D.The mean CCT of the myopic group was 543.8 +/- 35.40 microm, while for the emmetropic group it was 545.7 +/- 27.6 microm. The difference in mean CCT between the two groups was statistically insignificant (P = 0.5). There was no correlation between CCT and the degree of myopic spherical equivalent (r = -0.014, P = 0.939). This clinical study showed that there was no difference in CCT between emmetropic and myopic eyes. CCT did not correlate with the degree of myopia. It seems that the central cornea is not significantly involved in the process of myopic progression.International Ophthalmology 07/2008; 29(5):373-8.
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ABSTRACT: Die okuläre Hypertension bezeichnet einen über die „Norm“ ( > 21 mmHg) erhöhten Intraokulardruck (IOD). Der Kammerwinkel ist definitionsgemäß offen, glaukomtypische Gesichtsfeldausfälle und Papillenveränderungen fehlen. Es handelt sich um Individuen, die nicht an einem Glaukom leiden, wohl aber ein erhöhtes Risiko haben, ein Glaukom zu entwickeln. Um glaukomtypische Gesichtsfeldausfälle und Papillenveränderungen auszuschließen, ist eine ausführliche „Glaukombasisdiagnostik“ unabdingbar. Aufgrund des erhöhten Risikos, ein Glaukom zu entwickeln, sind feste Kontrollintervalle und eine standardisierte Untersuchung für das Follow-up ebenso zwingend erforderlich.Der Ophthalmologe 108(11). · 0.53 Impact Factor