Health benefits of nuts: potential role of antioxidants. Br J Nutr 96:S52-S60

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
British Journal Of Nutrition (Impact Factor: 3.45). 12/2006; 96 Suppl 2(S2):S52-60. DOI: 10.1017/BJN20061864
Source: PubMed


A diet rich in fruits, vegetables and minimally refined cereals is associated with lower risk for chronic degenerative diseases. Since oxidative stress is common in chronic degenerative disease, it has been assumed that dietary antioxidants may explain this protective effect. Every dietary plant contains numerous types of antioxidants with different properties. Many of these antioxidants cooperate in oxidative stress reduction in plants, and we hypothesize that many different antioxidants may also be needed for the proper protection of animal cells. To test this hypothesis, it is useful to identify dietary plants with high total antioxidant content. Several nuts are among the dietary plants with the highest content of total antioxidants. Of the tree nuts, walnuts, pecans and chestnuts have the highest contents of antioxidants. Walnuts contain more than 20 mmol antioxidants per 100 g, mostly in the walnut pellicles. Peanuts (a legume) also contribute significantly to dietary intake of antioxidants. These data are in accordance with our present extended analysis of an earlier report on nut intake and death attributed to various diseases in the Iowa Women's Health Study. We observed that the hazard ratio for total death rates showed a U-shaped association with nut/peanut butter consumption. Hazard ratio was 0.89 (CI = 0.81-0.97) and 0.81 (CI = 0.75-0.88) for nut/peanut butter intake once per week and 1-4 times per week, respectively. Death attributed to cardiovascular and coronary heart diseases showed strong and consistent reductions with increasing nut/peanut butter consumption. Further studies are needed to clarify whether antioxidants contribute to this apparent beneficial health effect of nuts.

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Available from: Lene Frost Andersen, Dec 20, 2014
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    • "und in both polar and nonpolar extracts , it is likely that multiple cytoprotective mechanisms are acting against vanadium induced oxidative cytotoxicity . For example , synergistic effects between both hydrophilic and lipophilic antioxidants in ethanolic but not aqueous extract could exist in which antioxidants recharge neighboring antioxidants ( Blomhoff et al . , 2006 ) . Another study found that quercetin and epicatechin regenerated a - tocopherol thereby eliciting a coantioxidant effect ( Pedrielli et al , 2002 ) . Almond extracts also demonstrated excellent metal chelating abilities ( Wijeratne et al . , 2006 ) . In summary our study has shown that sesame extracts , particularly the ethanolic extr"
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    ABSTRACT: Vanadium toxicity is a challenging problem to human and animal health with no entirely understanding cytotoxic mechanisms. Previous studies in vanadium toxicity showed involvement of oxidative stress in isolated liver hepatocytes and mitochondria via increasing of ROS formation, release of cytochrome c and ATP depletion after incubation with different concentrations (25-200 µM). Therefore, we aimed to investigate the protective effects of Sesamum indicum seed extract (100-300 μg/mL) against oxidative stress induced by vanadium on isolated rat hepatocytes. Our results showed that quite similar to Alpha-tocopherol (100 µM), different concentrations of extract (100-300 μg/mL) protected the isolated hepatocyte against all oxidative stress/cytotoxicity markers induced by vanadium in including cell lysis, ROS generation, mitochondrial membrane potential decrease and lysosomal membrane damage. Besides, vanadium induced mitochondrial/lysosomal toxic interaction and vanadium reductive activation mediated by glutathione in vanadium toxicity was significantly (P < 0.05) ameliorated by Sesamum indicum extracts. These findings suggested a hepato-protective role for extracts against liver injury resulted from vanadium toxicity. © 2015 Wiley Periodicals, Inc. Environ Toxicol, 2015. © 2015 Wiley Periodicals, Inc.
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    • "Besides the nutrition potential, groundnut has tremendous health benefits. Eating groundnut lowers a person " s risk of weight gain, promotes heart health, prevents certain cardiovascular diseases, reduces risk of coronary and Alzheimer " s diseases and lowers cholesterol in the blood stream (Blomhoff et al., 2006; Alper and Mattes, 2003; Awad et al., 2000; Morris et al., 2004). "
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    • "Remarkably, most phenolic antioxidants are located in the testa and more than 50% of them are lost owing to the removal of the testa during processing [29]. This fact, which was rarely taken into consideration in previous feeding trials with nuts, should not be overlooked in future studies. "
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